Pharmacophore modeling for identification of anti-IGF-1R drugs and in-vitro validation of fulvestrant as a potential inhibitor

Insulin-like growth factor 1 receptor (IGF-1R) is an important therapeutic target for breast cancer treatment. The alteration in the IGF-1R associated signaling network due to various genetic and environmental factors leads the system towards metastasis. The pharmacophore modeling and logical approa...

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Detalles Bibliográficos
Autores principales: Khalid, Samra, Hanif, Rumeza, Jabeen, Ishrat, Mansoor, Qaisar, Ismail, Muhammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963753/
https://www.ncbi.nlm.nih.gov/pubmed/29787591
http://dx.doi.org/10.1371/journal.pone.0196312

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963753/
https://www.ncbi.nlm.nih.gov/pubmed/29787591
http://dx.doi.org/10.1371/journal.pone.0196312

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