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Expression, purification, and inhibition profile of dihydrofolate reductase from the filarial nematode Wuchereria bancrofti

Filariasis is a tropical disease caused by the parasitic nematodes Wuchereria bancrofti and Brugia malayi. Known inhibitors of dihydrofolate reductase (DHFR) have been previously shown to kill Brugia malayi nematodes and to inhibit Brugia malayi DHFR (BmDHFR) at nanomolar concentrations. These data...

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Detalles Bibliográficos
Autores principales:	Tobias, Andrew M., Toska, Dea, Lange, Keith, Eck, Tyler, Bhat, Rohit, Janson, Cheryl A., Rotella, David P., Gubler, Ueli, Goodey, Nina M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963757/ https://www.ncbi.nlm.nih.gov/pubmed/29787565 http://dx.doi.org/10.1371/journal.pone.0197173

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