Cargando…

TDP-43 causes neurotoxicity and cytoskeletal dysfunction in primary cortical neurons

TDP-43-mediated proteinopathy is a key factor in the pathology of amyotrophic lateral sclerosis (ALS). A potential underlying mechanism is dysregulation of the cytoskeleton. Here we investigate the effects of expressing TDP-43 wild-type and M337V and Q331K mutant isoforms on cytoskeletal integrity a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Baskaran, Pranetha, Shaw, Christopher, Guthrie, Sarah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963761/ https://www.ncbi.nlm.nih.gov/pubmed/29787572 http://dx.doi.org/10.1371/journal.pone.0196528

Ejemplares similares

Retraction: TDP-43 causes neurotoxicity and cytoskeletal dysfunction in primary cortical neurons
Publicado: (2021)

Tar DNA-binding protein-43 (TDP-43) regulates axon growth in vitro and in vivo()
por: Tripathi, Vineeta Bhasker, et al.
Publicado: (2014)

Identification of Genetic Modifiers of TDP-43 Neurotoxicity in Drosophila
por: Zhan, Lihong, et al.
Publicado: (2013)

Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS
por: Mitchell, Jacqueline C, et al.
Publicado: (2015)

Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency
por: Zhang, Jiasheng, et al.
Publicado: (2020)

TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons
por: Vogt, Miriam A., et al.
Publicado: (2018)

Endolysosomal pathway activity protects cells from neurotoxic TDP-43
por: Leibiger, Christine, et al.
Publicado: (2018)

The Role of HDAC6 in TDP-43-Induced Neurotoxicity and UPS Impairment
por: Lee, Shinrye, et al.
Publicado: (2020)

Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice
por: Xu, Ya-Fei, et al.
Publicado: (2011)

TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans
por: Latimer, Caitlin S., et al.
Publicado: (2022)

Implications of TDP-43 in non-neuronal systems
por: Ke, Hao, et al.
Publicado: (2023)

Sarm1 deletion suppresses TDP-43-linked motor neuron degeneration and cortical spine loss
por: White, Matthew A., et al.
Publicado: (2019)

Distinct neurotoxic TDP-43 fibril polymorphs are generated by heterotypic interactions with α-Synuclein
por: Dhakal, Shailendra, et al.
Publicado: (2022)

TDP-43 and Limbic-Predominant Age-Related TDP-43 Encephalopathy
por: Zhang, Lumi, et al.
Publicado: (2020)

DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation
por: Deshimaru, Manami, et al.
Publicado: (2021)

Neuronal overexpression of hTDP-43 in Caenorhabditis elegans mimics the cellular pathology commonly observed in TDP-43 proteinopathies
por: Koopman, Mandy, et al.
Publicado: (2023)

Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models
por: Barmada, Sami J., et al.
Publicado: (2014)

Drosophila TDP-43 dysfunction in glia and muscle cells cause cytological and behavioural phenotypes that characterize ALS and FTLD
por: Diaper, Danielle C., et al.
Publicado: (2013)

The SARS-CoV-2 main protease induces neurotoxic TDP-43 cleavage and aggregates
por: Yang, Jiaxin, et al.
Publicado: (2023)

Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation
por: Gruijs da Silva, Lara A, et al.
Publicado: (2022)

TDP-43 misexpression causes defects in dendritic growth
por: Herzog, Josiah J., et al.
Publicado: (2017)

The Aggregation and Neurotoxicity of TDP-43 and Its ALS-Associated 25 kDa Fragment Are Differentially Affected by Molecular Chaperones in Drosophila
por: Gregory, Jenna M., et al.
Publicado: (2012)

Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction
por: Cannon, Ashley, et al.
Publicado: (2012)

Rodent Models of TDP-43 Proteinopathy: Investigating the Mechanisms of TDP-43-Mediated Neurodegeneration
por: Gendron, Tania F., et al.
Publicado: (2011)

Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation
por: Ormeño, Fernando, et al.
Publicado: (2020)

Evidence of cerebellar TDP-43 loss of function in FTLD-TDP
por: Pickles, Sarah, et al.
Publicado: (2022)

Analysis of TDP-43 and its binding partners in neurodegenerative diseases
por: Kattuah, Wejdan, et al.
Publicado: (2013)

Neuronal overexpression of human TDP-43 in Caenorhabditis elegans causes a range of sensorimotor phenotypes
por: Koopman, Mandy, et al.
Publicado: (2023)

Heterogeneity of cortical pTDP-43 inclusion morphologies in amyotrophic lateral sclerosis
por: Tan, Rachel H., et al.
Publicado: (2023)

Neurotoxic 43-kDa TAR DNA-binding Protein (TDP-43) Triggers Mitochondrion-dependent Programmed Cell Death in Yeast
por: Braun, Ralf J., et al.
Publicado: (2011)

TDP-43 crosses the divide
por: Leslie, Mitch
Publicado: (2015)

A C-Terminally Truncated TDP-43 Splice Isoform Exhibits Neuronal Specific Cytoplasmic Aggregation and Contributes to TDP-43 Pathology in ALS
por: Shenouda, Marc, et al.
Publicado: (2022)

TDP-43: From Alzheimer’s Disease to Limbic-Predominant Age-Related TDP-43 Encephalopathy
por: Huang, Wendi, et al.
Publicado: (2020)

TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy
por: Atkinson, Rachel, et al.
Publicado: (2021)

The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation
por: Rengifo-Gonzalez, Juan Carlos, et al.
Publicado: (2021)

Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43
por: Keating, Sean S., et al.
Publicado: (2023)

Does a loss of TDP-43 function cause neurodegeneration?
por: Xu, Zuo-Shang
Publicado: (2012)

Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation
por: Chang, Michael C., et al.
Publicado: (2017)

TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets
por: Scotter, Emma L., et al.
Publicado: (2015)

Identification of Neuronal RNA Targets of TDP-43-containing Ribonucleoprotein Complexes
por: Sephton, Chantelle F., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_5or2lu483o960i20g413305eml