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TDP-43 causes neurotoxicity and cytoskeletal dysfunction in primary cortical neurons

TDP-43-mediated proteinopathy is a key factor in the pathology of amyotrophic lateral sclerosis (ALS). A potential underlying mechanism is dysregulation of the cytoskeleton. Here we investigate the effects of expressing TDP-43 wild-type and M337V and Q331K mutant isoforms on cytoskeletal integrity a...

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Detalles Bibliográficos
Autores principales:	Baskaran, Pranetha, Shaw, Christopher, Guthrie, Sarah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963761/ https://www.ncbi.nlm.nih.gov/pubmed/29787572 http://dx.doi.org/10.1371/journal.pone.0196528

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