Brachytherapy for patients with uveal melanoma: historical perspectives and future treatment directions

Surgical management with enucleation was the primary treatment for uveal melanoma (UM) for over 100 years. The Collaborative Ocular Melanoma Study confirmed in 2001 that globe-preserving episcleral brachytherapy for UM was safe and effective, demonstrating no survival difference with enucleation. To...

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Autores principales: Brewington, Beatrice Y, Shao, Yusra F, Davidorf, Fredrick H, Cebulla, Colleen M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963830/
https://www.ncbi.nlm.nih.gov/pubmed/29844657
http://dx.doi.org/10.2147/OPTH.S129645
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author Brewington, Beatrice Y
Shao, Yusra F
Davidorf, Fredrick H
Cebulla, Colleen M
author_facet Brewington, Beatrice Y
Shao, Yusra F
Davidorf, Fredrick H
Cebulla, Colleen M
author_sort Brewington, Beatrice Y
collection PubMed
description Surgical management with enucleation was the primary treatment for uveal melanoma (UM) for over 100 years. The Collaborative Ocular Melanoma Study confirmed in 2001 that globe-preserving episcleral brachytherapy for UM was safe and effective, demonstrating no survival difference with enucleation. Today, brachytherapy is the most common form of radiotherapy for UM. We review the history of brachytherapy in the treatment of UM and the evolution of the procedure to incorporate fine-needle-aspiration biopsy techniques with DNA-and RNA-based genetic prognostic testing.
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spelling pubmed-59638302018-05-29 Brachytherapy for patients with uveal melanoma: historical perspectives and future treatment directions Brewington, Beatrice Y Shao, Yusra F Davidorf, Fredrick H Cebulla, Colleen M Clin Ophthalmol Review Surgical management with enucleation was the primary treatment for uveal melanoma (UM) for over 100 years. The Collaborative Ocular Melanoma Study confirmed in 2001 that globe-preserving episcleral brachytherapy for UM was safe and effective, demonstrating no survival difference with enucleation. Today, brachytherapy is the most common form of radiotherapy for UM. We review the history of brachytherapy in the treatment of UM and the evolution of the procedure to incorporate fine-needle-aspiration biopsy techniques with DNA-and RNA-based genetic prognostic testing. Dove Medical Press 2018-05-17 /pmc/articles/PMC5963830/ /pubmed/29844657 http://dx.doi.org/10.2147/OPTH.S129645 Text en © 2018 Brewington et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Brewington, Beatrice Y
Shao, Yusra F
Davidorf, Fredrick H
Cebulla, Colleen M
Brachytherapy for patients with uveal melanoma: historical perspectives and future treatment directions
title Brachytherapy for patients with uveal melanoma: historical perspectives and future treatment directions
title_full Brachytherapy for patients with uveal melanoma: historical perspectives and future treatment directions
title_fullStr Brachytherapy for patients with uveal melanoma: historical perspectives and future treatment directions
title_full_unstemmed Brachytherapy for patients with uveal melanoma: historical perspectives and future treatment directions
title_short Brachytherapy for patients with uveal melanoma: historical perspectives and future treatment directions
title_sort brachytherapy for patients with uveal melanoma: historical perspectives and future treatment directions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963830/
https://www.ncbi.nlm.nih.gov/pubmed/29844657
http://dx.doi.org/10.2147/OPTH.S129645
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