Etoposide Protects Mice from Radiation‐induced Bone Marrow Death

Etoposide is known to inhibit the activity of topoisomerase II, and to possess radiosensitizing effects. In this paper we show that pretreatment of mice with etoposide one day before whole‐body irradiation had a protective effect against radiation‐induced bone marrow death. The LD50/30 of mice given...

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Detalles Bibliográficos
Autores principales: Yamada, Sigeru, Ando, Koichi, Koike, Sachiko, Isono, Kaichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1990
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963894/
https://www.ncbi.nlm.nih.gov/pubmed/2110126
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02535.x
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author Yamada, Sigeru
Ando, Koichi
Koike, Sachiko
Isono, Kaichi
author_facet Yamada, Sigeru
Ando, Koichi
Koike, Sachiko
Isono, Kaichi
author_sort Yamada, Sigeru
collection PubMed
description Etoposide is known to inhibit the activity of topoisomerase II, and to possess radiosensitizing effects. In this paper we show that pretreatment of mice with etoposide one day before whole‐body irradiation had a protective effect against radiation‐induced bone marrow death. The LD50/30 of mice given radiation alone was 8.26 Gy while that of mice given etoposide one day before whole‐body irradiation was 10.35 Gy. The number of endogenous colony‐forming units surviving in whole body‐irradiated mice was significantly increased by pretreatment with etoposide.
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spelling pubmed-59638942019-04-16 Etoposide Protects Mice from Radiation‐induced Bone Marrow Death Yamada, Sigeru Ando, Koichi Koike, Sachiko Isono, Kaichi Jpn J Cancer Res Rapid Communication Etoposide is known to inhibit the activity of topoisomerase II, and to possess radiosensitizing effects. In this paper we show that pretreatment of mice with etoposide one day before whole‐body irradiation had a protective effect against radiation‐induced bone marrow death. The LD50/30 of mice given radiation alone was 8.26 Gy while that of mice given etoposide one day before whole‐body irradiation was 10.35 Gy. The number of endogenous colony‐forming units surviving in whole body‐irradiated mice was significantly increased by pretreatment with etoposide. Blackwell Publishing Ltd 1990-02 /pmc/articles/PMC5963894/ /pubmed/2110126 http://dx.doi.org/10.1111/j.1349-7006.1990.tb02535.x Text en
spellingShingle Rapid Communication
Yamada, Sigeru
Ando, Koichi
Koike, Sachiko
Isono, Kaichi
Etoposide Protects Mice from Radiation‐induced Bone Marrow Death
title Etoposide Protects Mice from Radiation‐induced Bone Marrow Death
title_full Etoposide Protects Mice from Radiation‐induced Bone Marrow Death
title_fullStr Etoposide Protects Mice from Radiation‐induced Bone Marrow Death
title_full_unstemmed Etoposide Protects Mice from Radiation‐induced Bone Marrow Death
title_short Etoposide Protects Mice from Radiation‐induced Bone Marrow Death
title_sort etoposide protects mice from radiation‐induced bone marrow death
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963894/
https://www.ncbi.nlm.nih.gov/pubmed/2110126
http://dx.doi.org/10.1111/j.1349-7006.1990.tb02535.x
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AT andokoichi etoposideprotectsmicefromradiationinducedbonemarrowdeath
AT koikesachiko etoposideprotectsmicefromradiationinducedbonemarrowdeath
AT isonokaichi etoposideprotectsmicefromradiationinducedbonemarrowdeath

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