Cargando…

Development and validation of the WebAd-Q Questionnaire to monitor adherence to HIV therapy

OBJECTIVE: To present the development and validation of the WebAd-Q Questionnaire, a self-report instrument to monitor adherence to antiretroviral therapy in HIV/AIDS centers in Brazil. METHODS: The WebAd-Q is an electronic questionnaire that has three questions about the use of antiretrovirals in t...

Descripción completa

Detalles Bibliográficos
Autores principales: Vale, Felipe Campos, de Santa-Helena, Ernani Tiaraju, Santos, Maria Altenfelder, Carvalho, Wania Maria do Espirito Santo, Menezes, Paulo Rossi, Basso, Caritas Relva, Silva, Mariliza Henrique, Alves, Ana Maroso, Nemes, Maria Ines Battistella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculdade de Saúde Pública da Universidade de São Paulo 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963908/
https://www.ncbi.nlm.nih.gov/pubmed/29846437
http://dx.doi.org/10.11606/S1518-8787.2018052000337
_version_ 1783325095275528192
author Vale, Felipe Campos
de Santa-Helena, Ernani Tiaraju
Santos, Maria Altenfelder
Carvalho, Wania Maria do Espirito Santo
Menezes, Paulo Rossi
Basso, Caritas Relva
Silva, Mariliza Henrique
Alves, Ana Maroso
Nemes, Maria Ines Battistella
author_facet Vale, Felipe Campos
de Santa-Helena, Ernani Tiaraju
Santos, Maria Altenfelder
Carvalho, Wania Maria do Espirito Santo
Menezes, Paulo Rossi
Basso, Caritas Relva
Silva, Mariliza Henrique
Alves, Ana Maroso
Nemes, Maria Ines Battistella
author_sort Vale, Felipe Campos
collection PubMed
description OBJECTIVE: To present the development and validation of the WebAd-Q Questionnaire, a self-report instrument to monitor adherence to antiretroviral therapy in HIV/AIDS centers in Brazil. METHODS: The WebAd-Q is an electronic questionnaire that has three questions about the use of antiretrovirals in the last week. It was constructed from interviews and focus groups with 38 patients. Its validity was tested in a study with a sample of 90 adult patients on antiretroviral therapy for at least three months. We used electronic monitoring bottles, pill counting, and self-report interview to compare adherence. The WebAd-Q was answered on the sixtieth day, twice, with at least one hour of interval. The viral load of the patients was obtained from the service records. We have analyzed the agreement between the answers to the WebAd-Q, the associations, and the correlations with viral load and performance compared to other measures of adherence. RESULTS: Among the invited patients, 74 (82.2%) answered the WebAd-Q. No difficulties were reported to answer the questionnaire. The average answer time was 5 min 47 sec. The set of three questions of the WebAd-Q obtained agreement of 89.8%, with Kappa of 0.77 (95%CI 0.61–0.94). The non-adherence answers of the WebAd-Q were associated with detectable viral load. We obtained moderate viral load correlations with the non-adherence scale according to the WebAd-Q. For the three questions of the WebAd-Q, patients with non-adherence answers were also reported as less adherent according to the other measures of adherence. CONCLUSIONS: The WebAd-Q answered all the issues considered relevant in the validation of questionnaires, was well understood by patients, was associated with viral load, and obtained good agreement and good performance compared to the other measures. The feasibility analysis of its implementation still depends on a national study on its applicability.
format Online
Article
Text
id pubmed-5963908
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Faculdade de Saúde Pública da Universidade de São Paulo
record_format MEDLINE/PubMed
spelling pubmed-59639082018-05-30 Development and validation of the WebAd-Q Questionnaire to monitor adherence to HIV therapy Vale, Felipe Campos de Santa-Helena, Ernani Tiaraju Santos, Maria Altenfelder Carvalho, Wania Maria do Espirito Santo Menezes, Paulo Rossi Basso, Caritas Relva Silva, Mariliza Henrique Alves, Ana Maroso Nemes, Maria Ines Battistella Rev Saude Publica Original Article OBJECTIVE: To present the development and validation of the WebAd-Q Questionnaire, a self-report instrument to monitor adherence to antiretroviral therapy in HIV/AIDS centers in Brazil. METHODS: The WebAd-Q is an electronic questionnaire that has three questions about the use of antiretrovirals in the last week. It was constructed from interviews and focus groups with 38 patients. Its validity was tested in a study with a sample of 90 adult patients on antiretroviral therapy for at least three months. We used electronic monitoring bottles, pill counting, and self-report interview to compare adherence. The WebAd-Q was answered on the sixtieth day, twice, with at least one hour of interval. The viral load of the patients was obtained from the service records. We have analyzed the agreement between the answers to the WebAd-Q, the associations, and the correlations with viral load and performance compared to other measures of adherence. RESULTS: Among the invited patients, 74 (82.2%) answered the WebAd-Q. No difficulties were reported to answer the questionnaire. The average answer time was 5 min 47 sec. The set of three questions of the WebAd-Q obtained agreement of 89.8%, with Kappa of 0.77 (95%CI 0.61–0.94). The non-adherence answers of the WebAd-Q were associated with detectable viral load. We obtained moderate viral load correlations with the non-adherence scale according to the WebAd-Q. For the three questions of the WebAd-Q, patients with non-adherence answers were also reported as less adherent according to the other measures of adherence. CONCLUSIONS: The WebAd-Q answered all the issues considered relevant in the validation of questionnaires, was well understood by patients, was associated with viral load, and obtained good agreement and good performance compared to the other measures. The feasibility analysis of its implementation still depends on a national study on its applicability. Faculdade de Saúde Pública da Universidade de São Paulo 2018-05-18 /pmc/articles/PMC5963908/ /pubmed/29846437 http://dx.doi.org/10.11606/S1518-8787.2018052000337 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Vale, Felipe Campos
de Santa-Helena, Ernani Tiaraju
Santos, Maria Altenfelder
Carvalho, Wania Maria do Espirito Santo
Menezes, Paulo Rossi
Basso, Caritas Relva
Silva, Mariliza Henrique
Alves, Ana Maroso
Nemes, Maria Ines Battistella
Development and validation of the WebAd-Q Questionnaire to monitor adherence to HIV therapy
title Development and validation of the WebAd-Q Questionnaire to monitor adherence to HIV therapy
title_full Development and validation of the WebAd-Q Questionnaire to monitor adherence to HIV therapy
title_fullStr Development and validation of the WebAd-Q Questionnaire to monitor adherence to HIV therapy
title_full_unstemmed Development and validation of the WebAd-Q Questionnaire to monitor adherence to HIV therapy
title_short Development and validation of the WebAd-Q Questionnaire to monitor adherence to HIV therapy
title_sort development and validation of the webad-q questionnaire to monitor adherence to hiv therapy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963908/
https://www.ncbi.nlm.nih.gov/pubmed/29846437
http://dx.doi.org/10.11606/S1518-8787.2018052000337
work_keys_str_mv AT valefelipecampos developmentandvalidationofthewebadqquestionnairetomonitoradherencetohivtherapy
AT desantahelenaernanitiaraju developmentandvalidationofthewebadqquestionnairetomonitoradherencetohivtherapy
AT santosmariaaltenfelder developmentandvalidationofthewebadqquestionnairetomonitoradherencetohivtherapy
AT carvalhowaniamariadoespiritosanto developmentandvalidationofthewebadqquestionnairetomonitoradherencetohivtherapy
AT menezespaulorossi developmentandvalidationofthewebadqquestionnairetomonitoradherencetohivtherapy
AT bassocaritasrelva developmentandvalidationofthewebadqquestionnairetomonitoradherencetohivtherapy
AT silvamarilizahenrique developmentandvalidationofthewebadqquestionnairetomonitoradherencetohivtherapy
AT alvesanamaroso developmentandvalidationofthewebadqquestionnairetomonitoradherencetohivtherapy
AT nemesmariainesbattistella developmentandvalidationofthewebadqquestionnairetomonitoradherencetohivtherapy