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Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment

In type 2 diabetes, amyloid oligomers, chronic hyperglycemia, lipotoxicity, and pro-inflammatory cytokines are detrimental to beta-cells, causing apoptosis and impaired insulin secretion. The histone acetyl transferase p300, involved in remodeling of chromatin structure by epigenetic mechanisms, is...

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Detalles Bibliográficos
Autores principales:	Ruiz, Lucie, Gurlo, Tatyana, Ravier, Magalie A., Wojtusciszyn, Anne, Mathieu, Julia, Brown, Matthew R., Broca, Christophe, Bertrand, Gyslaine, Butler, Peter C., Matveyenko, Aleksey V., Dalle, Stéphane, Costes, Safia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964068/ https://www.ncbi.nlm.nih.gov/pubmed/29789539 http://dx.doi.org/10.1038/s41419-018-0603-0

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