Vorinostat and quinacrine have synergistic effects in T-cell acute lymphoblastic leukemia through reactive oxygen species increase and mitophagy inhibition

Despite recent progress in the treatment, the outcome of adult acute T-cell lymphoblastic leukemia (T-ALL) is poor. Development of novel approach to combat this disease is urgently required. Vorinostat, a pan-histone deacetylase (HDAC) inhibitor, exerts promising anticancer activity in a variety of...

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Detalles Bibliográficos
Autores principales: Jing, Bo, Jin, Jin, Xiang, Rufang, Liu, Meng, Yang, Li, Tong, Yin, Xiao, Xinhua, Lei, Hu, Liu, Wei, Xu, Hanzhang, Deng, Jiong, Zhou, Li, Wu, Yingli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964102/
https://www.ncbi.nlm.nih.gov/pubmed/29789603
http://dx.doi.org/10.1038/s41419-018-0679-6

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