Transcriptome analysis of the adult human Klinefelter testis and cellularity-matched controls reveals disturbed differentiation of Sertoli- and Leydig cells

The most common human sex chromosomal disorder is Klinefelter syndrome (KS; 47,XXY). Adult patients with KS display a diverse phenotype but are nearly always infertile, due to testicular degeneration at puberty. To identify mechanisms causing the selective destruction of the seminiferous epithelium,...

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Detalles Bibliográficos
Autores principales: Winge, Sofia Boeg, Dalgaard, Marlene Danner, Belling, Kirstine G, Jensen, Jacob Malte, Nielsen, John Erik, Aksglaede, Lise, Schierup, Mikkel Heide, Brunak, Søren, Skakkebæk, Niels Erik, Juul, Anders, Rajpert-De Meyts, Ewa, Almstrup, Kristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964117/
https://www.ncbi.nlm.nih.gov/pubmed/29789566
http://dx.doi.org/10.1038/s41419-018-0671-1

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