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Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation

The relative importance of plasma membrane-localized LAT versus vesicular LAT for microcluster formation and T-cell receptor (TCR) activation is unclear. Here, we show the sequence of events in LAT microcluster formation and vesicle delivery, using lattice light sheet microscopy to image a T cell fr...

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Detalles Bibliográficos
Autores principales:	Balagopalan, Lakshmi, Yi, Jason, Nguyen, Tiffany, McIntire, Katherine M., Harned, Adam S., Narayan, Kedar, Samelson, Lawrence E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964120/ https://www.ncbi.nlm.nih.gov/pubmed/29789604 http://dx.doi.org/10.1038/s41467-018-04419-x

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