Endogenous authentic OCT4A proteins directly regulate FOS/AP-1 transcription in somatic cancer cells

OCT4A is well established as a master transcription factor for pluripotent stem cell (PSC) self-renewal and a pioneer factor for initiating somatic cell reprogramming, yet its presence and functionality in somatic cancer cells remain controversial and obscure. By combining the CRISPR-Cas9-based gene...

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Detalles Bibliográficos
Autores principales: Zhou, Yanwen, Chen, Xinyu, Kang, Bo, She, Shiqi, Zhang, Xiaobing, Chen, Cheng, Li, Wenxin, Chen, Wenjie, Dan, Songsong, Pan, Xiaoyun, Liu, Xiaoli, He, Jianqin, Zhao, Qingwei, Zhu, Chenggang, Peng, Ling, Wang, Haoyi, Yao, Hangping, Cao, Hongcui, Li, Lanjuan, Herlyn, Meenhard, Wang, Ying-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964179/
https://www.ncbi.nlm.nih.gov/pubmed/29789579
http://dx.doi.org/10.1038/s41419-018-0606-x

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