The proton pump inhibitor pantoprazole disrupts protein degradation systems and sensitizes cancer cells to death under various stresses

Proton pump inhibitors (PPIs) play a role in antitumor activity, with studies showing specialized impacts of PPIs on cancer cell apoptosis, metastasis, and autophagy. In this study, we demonstrated that pantoprazole (PPI) increased autophagosomes formation and affected autophagic flux depending on t...

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Detalles Bibliográficos
Autores principales: Cao, Yu, Chen, Min, Tang, Dehua, Yan, Hongli, Ding, Xiwei, Zhou, Fan, Zhang, Mingming, Xu, Guifang, Zhang, Weijie, Zhang, Shu, Zhuge, Yuzheng, Wang, Lei, Zou, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964200/
https://www.ncbi.nlm.nih.gov/pubmed/29789637
http://dx.doi.org/10.1038/s41419-018-0642-6

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