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Enhancer of zeste homolog 2-catalysed H3K27 trimethylation plays a key role in acute-on-chronic liver failure via TNF-mediated pathway

Acute-on-chronic liver failure is mainly due to host immunity self-destruction. The histone H3 lysine 27 (H3K27) trimethylating enzyme, enhancer of zeste homolog 2 (EZH2) mediates epigenetic silencing of gene expression and regulates immunity, also involves pathogenesis of several liver diseases. Th...

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Detalles Bibliográficos
Autores principales:	Zhou, Tianhui, Sun, Ye, Li, Ming, Ding, Yongsen, Yin, Rongkun, Li, Ziqiang, Xie, Qing, Bao, Shisan, Cai, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964223/ https://www.ncbi.nlm.nih.gov/pubmed/29789597 http://dx.doi.org/10.1038/s41419-018-0670-2

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