Duodenal Adenocarcinoma of Brunner Gland Origin: A Case Report

We report a case of adenocarcinoma originating from the duodenal Brunner glands in a 47-year-old female patient. The lesion was 0.8 cm in extent and located at the posterior wall of the first part of the duodenum. Histologically, the tumor showed transition from non-neoplastic Brunner glands through...

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Autores principales: Moon, Ji Hye, Lee, Kyoungbun, Yang, Han-Kwang, Kim, Woo Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Pathologists and the Korean Society for Cytopathology 2018
Materias:
Case Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964285/
https://www.ncbi.nlm.nih.gov/pubmed/29281782
http://dx.doi.org/10.4132/jptm.2017.10.09
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author Moon, Ji Hye
Lee, Kyoungbun
Yang, Han-Kwang
Kim, Woo Ho
author_facet Moon, Ji Hye
Lee, Kyoungbun
Yang, Han-Kwang
Kim, Woo Ho
author_sort Moon, Ji Hye
collection PubMed
description We report a case of adenocarcinoma originating from the duodenal Brunner glands in a 47-year-old female patient. The lesion was 0.8 cm in extent and located at the posterior wall of the first part of the duodenum. Histologically, the tumor showed transition from non-neoplastic Brunner glands through dysplastic epithelium into adenocarcinoma. The carcinoma cells were strongly positive for MUC6 protein, which is an epithelial marker for the Brunner glands. Tumor protein p53 was overexpressed in the carcinoma cells, but not in the non-neoplastic or dysplastic epithelium. Dystrophic calcification was predominant. This is the first case report of duodenal adenocarcinoma of Brunner gland origin in Korea.
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spelling pubmed-59642852018-05-31 Duodenal Adenocarcinoma of Brunner Gland Origin: A Case Report Moon, Ji Hye Lee, Kyoungbun Yang, Han-Kwang Kim, Woo Ho J Pathol Transl Med Case Study We report a case of adenocarcinoma originating from the duodenal Brunner glands in a 47-year-old female patient. The lesion was 0.8 cm in extent and located at the posterior wall of the first part of the duodenum. Histologically, the tumor showed transition from non-neoplastic Brunner glands through dysplastic epithelium into adenocarcinoma. The carcinoma cells were strongly positive for MUC6 protein, which is an epithelial marker for the Brunner glands. Tumor protein p53 was overexpressed in the carcinoma cells, but not in the non-neoplastic or dysplastic epithelium. Dystrophic calcification was predominant. This is the first case report of duodenal adenocarcinoma of Brunner gland origin in Korea. The Korean Society of Pathologists and the Korean Society for Cytopathology 2018-05 2017-12-27 /pmc/articles/PMC5964285/ /pubmed/29281782 http://dx.doi.org/10.4132/jptm.2017.10.09 Text en © 2018 The Korean Society of Pathologists/The Korean Society for Cytopathology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Study
Moon, Ji Hye
Lee, Kyoungbun
Yang, Han-Kwang
Kim, Woo Ho
Duodenal Adenocarcinoma of Brunner Gland Origin: A Case Report
title Duodenal Adenocarcinoma of Brunner Gland Origin: A Case Report
title_full Duodenal Adenocarcinoma of Brunner Gland Origin: A Case Report
title_fullStr Duodenal Adenocarcinoma of Brunner Gland Origin: A Case Report
title_full_unstemmed Duodenal Adenocarcinoma of Brunner Gland Origin: A Case Report
title_short Duodenal Adenocarcinoma of Brunner Gland Origin: A Case Report
title_sort duodenal adenocarcinoma of brunner gland origin: a case report
topic Case Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964285/
https://www.ncbi.nlm.nih.gov/pubmed/29281782
http://dx.doi.org/10.4132/jptm.2017.10.09
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AT leekyoungbun duodenaladenocarcinomaofbrunnerglandoriginacasereport
AT yanghankwang duodenaladenocarcinomaofbrunnerglandoriginacasereport
AT kimwooho duodenaladenocarcinomaofbrunnerglandoriginacasereport

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