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Effects of a New Nano-Silver Fluoride-Containing Dentifrice on Demineralization of Enamel and Streptococcus mutans Adhesion and Acidogenicity
An experimental dentifrice containing nano-silver fluoride (NSF) and a sodium fluoride (NaF) toothpaste were tested in vitro, against S. mutans, to evaluate the minimal inhibitory concentration (MIC), minimal bactericidal concentration (MBC), antiadherence, antiacid, enamel microhardness, and OCT. T...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964412/ https://www.ncbi.nlm.nih.gov/pubmed/29853891 http://dx.doi.org/10.1155/2018/1351925 |
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author | Teixeira, Joás Araújo Silva, Amitis Vieira Costa e dos Santos Júnior, Valdeci Elias de Melo Júnior, Paulo Correia Arnaud, Manuela Lima, Maria Goretti Flores, Miguel Angel Pelagio Stamford, Thayza Christina Montenegro Dias Pereira, José Ricardo Ribeiro Targino, Andréa Gadelha Galembeck, André Rosenblatt, Aronita |
author_facet | Teixeira, Joás Araújo Silva, Amitis Vieira Costa e dos Santos Júnior, Valdeci Elias de Melo Júnior, Paulo Correia Arnaud, Manuela Lima, Maria Goretti Flores, Miguel Angel Pelagio Stamford, Thayza Christina Montenegro Dias Pereira, José Ricardo Ribeiro Targino, Andréa Gadelha Galembeck, André Rosenblatt, Aronita |
author_sort | Teixeira, Joás Araújo |
collection | PubMed |
description | An experimental dentifrice containing nano-silver fluoride (NSF) and a sodium fluoride (NaF) toothpaste were tested in vitro, against S. mutans, to evaluate the minimal inhibitory concentration (MIC), minimal bactericidal concentration (MBC), antiadherence, antiacid, enamel microhardness, and OCT. The microdilution technique was used to determine the MIC and MBC. Fragments of deciduous enamel were treated with dentifrice slurries, containing bacterial suspension and PBS-treated saliva. The quantification of the microorganisms that adhered to the enamel was determined after 24 hours of incubation, and media pH readings were performed after 2 hours and 24 hours. Deciduous teeth were evaluated for microhardness and OCT during 14 days of pH cycling. Data were statistically analyzed using Student's t-test, Mann–Whitney U test, ANOVA, and Tukey tests at 5% of significance. Dentifrices containing NSF presented a lower MIC and higher statistically significant results compared to NaF dentifrices with respect to preventing bacterial adhesion and pH decreases. NSF and NaF dentifrices showed the same ability to avoid enamel demineralization corroborated by the OCT images. The NSF formulation had a better antibacterial effect compared to NaF dentifrices and similar action on the demineralization of enamel indicating their potential effectiveness to prevent caries. |
format | Online Article Text |
id | pubmed-5964412 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-59644122018-05-31 Effects of a New Nano-Silver Fluoride-Containing Dentifrice on Demineralization of Enamel and Streptococcus mutans Adhesion and Acidogenicity Teixeira, Joás Araújo Silva, Amitis Vieira Costa e dos Santos Júnior, Valdeci Elias de Melo Júnior, Paulo Correia Arnaud, Manuela Lima, Maria Goretti Flores, Miguel Angel Pelagio Stamford, Thayza Christina Montenegro Dias Pereira, José Ricardo Ribeiro Targino, Andréa Gadelha Galembeck, André Rosenblatt, Aronita Int J Dent Research Article An experimental dentifrice containing nano-silver fluoride (NSF) and a sodium fluoride (NaF) toothpaste were tested in vitro, against S. mutans, to evaluate the minimal inhibitory concentration (MIC), minimal bactericidal concentration (MBC), antiadherence, antiacid, enamel microhardness, and OCT. The microdilution technique was used to determine the MIC and MBC. Fragments of deciduous enamel were treated with dentifrice slurries, containing bacterial suspension and PBS-treated saliva. The quantification of the microorganisms that adhered to the enamel was determined after 24 hours of incubation, and media pH readings were performed after 2 hours and 24 hours. Deciduous teeth were evaluated for microhardness and OCT during 14 days of pH cycling. Data were statistically analyzed using Student's t-test, Mann–Whitney U test, ANOVA, and Tukey tests at 5% of significance. Dentifrices containing NSF presented a lower MIC and higher statistically significant results compared to NaF dentifrices with respect to preventing bacterial adhesion and pH decreases. NSF and NaF dentifrices showed the same ability to avoid enamel demineralization corroborated by the OCT images. The NSF formulation had a better antibacterial effect compared to NaF dentifrices and similar action on the demineralization of enamel indicating their potential effectiveness to prevent caries. Hindawi 2018-05-08 /pmc/articles/PMC5964412/ /pubmed/29853891 http://dx.doi.org/10.1155/2018/1351925 Text en Copyright © 2018 Joás Araújo Teixeira et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Teixeira, Joás Araújo Silva, Amitis Vieira Costa e dos Santos Júnior, Valdeci Elias de Melo Júnior, Paulo Correia Arnaud, Manuela Lima, Maria Goretti Flores, Miguel Angel Pelagio Stamford, Thayza Christina Montenegro Dias Pereira, José Ricardo Ribeiro Targino, Andréa Gadelha Galembeck, André Rosenblatt, Aronita Effects of a New Nano-Silver Fluoride-Containing Dentifrice on Demineralization of Enamel and Streptococcus mutans Adhesion and Acidogenicity |
title | Effects of a New Nano-Silver Fluoride-Containing Dentifrice on Demineralization of Enamel and Streptococcus mutans Adhesion and Acidogenicity |
title_full | Effects of a New Nano-Silver Fluoride-Containing Dentifrice on Demineralization of Enamel and Streptococcus mutans Adhesion and Acidogenicity |
title_fullStr | Effects of a New Nano-Silver Fluoride-Containing Dentifrice on Demineralization of Enamel and Streptococcus mutans Adhesion and Acidogenicity |
title_full_unstemmed | Effects of a New Nano-Silver Fluoride-Containing Dentifrice on Demineralization of Enamel and Streptococcus mutans Adhesion and Acidogenicity |
title_short | Effects of a New Nano-Silver Fluoride-Containing Dentifrice on Demineralization of Enamel and Streptococcus mutans Adhesion and Acidogenicity |
title_sort | effects of a new nano-silver fluoride-containing dentifrice on demineralization of enamel and streptococcus mutans adhesion and acidogenicity |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964412/ https://www.ncbi.nlm.nih.gov/pubmed/29853891 http://dx.doi.org/10.1155/2018/1351925 |
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