A haunted beast: Targeting STAT5B(N642H) in T-Cell Neoplasia

The somatic hot spot mutation STAT5B(N642H) was found in many T cell leukemia/lymphoma patients. We generated and analyzed a transgenic mouse model with hematopoietic STAT5B(N642H) expression that caused aggressive T-cell leukemia/lymphomas. Herein, we discuss the scientific merit of our model and i...

Descripción completa

Detalles Bibliográficos
Autores principales: Pham, Ha Thi Thanh, Hengstschläger, Markus, Moriggl, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964446/
https://www.ncbi.nlm.nih.gov/pubmed/29876519
http://dx.doi.org/10.1080/23723556.2018.1435181
_version_ 1783325181081550848
author Pham, Ha Thi Thanh
Hengstschläger, Markus
Moriggl, Richard
author_facet Pham, Ha Thi Thanh
Hengstschläger, Markus
Moriggl, Richard
author_sort Pham, Ha Thi Thanh
collection PubMed
description The somatic hot spot mutation STAT5B(N642H) was found in many T cell leukemia/lymphoma patients. We generated and analyzed a transgenic mouse model with hematopoietic STAT5B(N642H) expression that caused aggressive T-cell leukemia/lymphomas. Herein, we discuss the scientific merit of our model and its relevance for pre-clinical studies.
format Online
Article
Text
id pubmed-5964446
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-59644462018-06-04 A haunted beast: Targeting STAT5B(N642H) in T-Cell Neoplasia Pham, Ha Thi Thanh Hengstschläger, Markus Moriggl, Richard Mol Cell Oncol Author's Views The somatic hot spot mutation STAT5B(N642H) was found in many T cell leukemia/lymphoma patients. We generated and analyzed a transgenic mouse model with hematopoietic STAT5B(N642H) expression that caused aggressive T-cell leukemia/lymphomas. Herein, we discuss the scientific merit of our model and its relevance for pre-clinical studies. Taylor & Francis 2018-03-28 /pmc/articles/PMC5964446/ /pubmed/29876519 http://dx.doi.org/10.1080/23723556.2018.1435181 Text en © 2018 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Pham, Ha Thi Thanh
Hengstschläger, Markus
Moriggl, Richard
A haunted beast: Targeting STAT5B(N642H) in T-Cell Neoplasia
title A haunted beast: Targeting STAT5B(N642H) in T-Cell Neoplasia
title_full A haunted beast: Targeting STAT5B(N642H) in T-Cell Neoplasia
title_fullStr A haunted beast: Targeting STAT5B(N642H) in T-Cell Neoplasia
title_full_unstemmed A haunted beast: Targeting STAT5B(N642H) in T-Cell Neoplasia
title_short A haunted beast: Targeting STAT5B(N642H) in T-Cell Neoplasia
title_sort haunted beast: targeting stat5b(n642h) in t-cell neoplasia
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964446/
https://www.ncbi.nlm.nih.gov/pubmed/29876519
http://dx.doi.org/10.1080/23723556.2018.1435181
work_keys_str_mv AT phamhathithanh ahauntedbeasttargetingstat5bn642hintcellneoplasia
AT hengstschlagermarkus ahauntedbeasttargetingstat5bn642hintcellneoplasia
AT morigglrichard ahauntedbeasttargetingstat5bn642hintcellneoplasia
AT phamhathithanh hauntedbeasttargetingstat5bn642hintcellneoplasia
AT hengstschlagermarkus hauntedbeasttargetingstat5bn642hintcellneoplasia
AT morigglrichard hauntedbeasttargetingstat5bn642hintcellneoplasia

Ejemplares similares