The calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design

The apicomplexan protozoan parasites include the causative agents of animal and human diseases ranging from malaria (Plasmodium spp.) to toxoplasmosis (Toxoplasma gondii). The complex life cycle of T. gondii is regulated by a unique family of calcium-dependent protein kinases (CDPKs) that have becom...

Descripción completa

Detalles Bibliográficos
Autores principales: CARDEW, EMILY M., VERLINDE, CHRISTOPHE L. M. J., POHL, EHMKE
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2018
Materias:
Special Issue Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964469/
https://www.ncbi.nlm.nih.gov/pubmed/29191253
http://dx.doi.org/10.1017/S0031182017001901
_version_ 1783325185784414208
author CARDEW, EMILY M.
VERLINDE, CHRISTOPHE L. M. J.
POHL, EHMKE
author_facet CARDEW, EMILY M.
VERLINDE, CHRISTOPHE L. M. J.
POHL, EHMKE
author_sort CARDEW, EMILY M.
collection PubMed
description The apicomplexan protozoan parasites include the causative agents of animal and human diseases ranging from malaria (Plasmodium spp.) to toxoplasmosis (Toxoplasma gondii). The complex life cycle of T. gondii is regulated by a unique family of calcium-dependent protein kinases (CDPKs) that have become the target of intensive efforts to develop new therapeutics. In this review, we will summarize structure-based strategies, recent successes and future directions in the pursuit of specific and selective inhibitors of T. gondii CDPK1.
format Online
Article
Text
id pubmed-5964469
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Cambridge University Press
record_format MEDLINE/PubMed
spelling pubmed-59644692018-05-25 The calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design CARDEW, EMILY M. VERLINDE, CHRISTOPHE L. M. J. POHL, EHMKE Parasitology Special Issue Review The apicomplexan protozoan parasites include the causative agents of animal and human diseases ranging from malaria (Plasmodium spp.) to toxoplasmosis (Toxoplasma gondii). The complex life cycle of T. gondii is regulated by a unique family of calcium-dependent protein kinases (CDPKs) that have become the target of intensive efforts to develop new therapeutics. In this review, we will summarize structure-based strategies, recent successes and future directions in the pursuit of specific and selective inhibitors of T. gondii CDPK1. Cambridge University Press 2018-02 /pmc/articles/PMC5964469/ /pubmed/29191253 http://dx.doi.org/10.1017/S0031182017001901 Text en © Cambridge University Press 2017 http://creativecommons.org/licenses/by/4.0/ This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Special Issue Review
CARDEW, EMILY M.
VERLINDE, CHRISTOPHE L. M. J.
POHL, EHMKE
The calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design
title The calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design
title_full The calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design
title_fullStr The calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design
title_full_unstemmed The calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design
title_short The calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design
title_sort calcium-dependent protein kinase 1 from toxoplasma gondii as target for structure-based drug design
topic Special Issue Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964469/
https://www.ncbi.nlm.nih.gov/pubmed/29191253
http://dx.doi.org/10.1017/S0031182017001901
work_keys_str_mv AT cardewemilym thecalciumdependentproteinkinase1fromtoxoplasmagondiiastargetforstructurebaseddrugdesign
AT verlindechristophelmj thecalciumdependentproteinkinase1fromtoxoplasmagondiiastargetforstructurebaseddrugdesign
AT pohlehmke thecalciumdependentproteinkinase1fromtoxoplasmagondiiastargetforstructurebaseddrugdesign
AT cardewemilym calciumdependentproteinkinase1fromtoxoplasmagondiiastargetforstructurebaseddrugdesign
AT verlindechristophelmj calciumdependentproteinkinase1fromtoxoplasmagondiiastargetforstructurebaseddrugdesign
AT pohlehmke calciumdependentproteinkinase1fromtoxoplasmagondiiastargetforstructurebaseddrugdesign

Ejemplares similares