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Neutropenic Enterocolitis in a Pediatric Heart Transplant Recipient on Multiple Immunosuppressants
Neutropenic enterocolitis (NE) historically primarily affects pediatric patients with leukemia who are undergoing chemotherapy or who have recently received bone marrow transplants. Although a few case reports have shown NE occurring outside of this typical population, to our knowledge, this is the...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964482/ https://www.ncbi.nlm.nih.gov/pubmed/29854547 http://dx.doi.org/10.1155/2018/3264921 |
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author | Miller, Emily E. Reardon, Leigh Christopher |
author_facet | Miller, Emily E. Reardon, Leigh Christopher |
author_sort | Miller, Emily E. |
collection | PubMed |
description | Neutropenic enterocolitis (NE) historically primarily affects pediatric patients with leukemia who are undergoing chemotherapy or who have recently received bone marrow transplants. Although a few case reports have shown NE occurring outside of this typical population, to our knowledge, this is the first published case of NE occurring in the setting of pediatric heart transplant. This patient was diagnosed several months after pediatric heart transplant, with radiographs showing evidence of pneumatosis intestinalis. Although NE does not typically affect solid organ transplant patients, this patient had a variety of risk factors that may have predisposed her to development of NE such as severe neutropenia, supratherapeutic tacrolimus level, immunosuppression with cytotoxic agents, and elevated Epstein-Barr viral load. Fortunately, this patient improved with bowel rest, fluids, antibiotics, and alteration of her immunosuppressive regimen. However, NE can be fatal, and thus it is an important condition to consider, even in patients without leukemia or on chemotherapeutic regimens. |
format | Online Article Text |
id | pubmed-5964482 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-59644822018-05-31 Neutropenic Enterocolitis in a Pediatric Heart Transplant Recipient on Multiple Immunosuppressants Miller, Emily E. Reardon, Leigh Christopher Case Rep Transplant Case Report Neutropenic enterocolitis (NE) historically primarily affects pediatric patients with leukemia who are undergoing chemotherapy or who have recently received bone marrow transplants. Although a few case reports have shown NE occurring outside of this typical population, to our knowledge, this is the first published case of NE occurring in the setting of pediatric heart transplant. This patient was diagnosed several months after pediatric heart transplant, with radiographs showing evidence of pneumatosis intestinalis. Although NE does not typically affect solid organ transplant patients, this patient had a variety of risk factors that may have predisposed her to development of NE such as severe neutropenia, supratherapeutic tacrolimus level, immunosuppression with cytotoxic agents, and elevated Epstein-Barr viral load. Fortunately, this patient improved with bowel rest, fluids, antibiotics, and alteration of her immunosuppressive regimen. However, NE can be fatal, and thus it is an important condition to consider, even in patients without leukemia or on chemotherapeutic regimens. Hindawi 2018-05-08 /pmc/articles/PMC5964482/ /pubmed/29854547 http://dx.doi.org/10.1155/2018/3264921 Text en Copyright © 2018 Emily E. Miller and Leigh Christopher Reardon. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Miller, Emily E. Reardon, Leigh Christopher Neutropenic Enterocolitis in a Pediatric Heart Transplant Recipient on Multiple Immunosuppressants |
title | Neutropenic Enterocolitis in a Pediatric Heart Transplant Recipient on Multiple Immunosuppressants |
title_full | Neutropenic Enterocolitis in a Pediatric Heart Transplant Recipient on Multiple Immunosuppressants |
title_fullStr | Neutropenic Enterocolitis in a Pediatric Heart Transplant Recipient on Multiple Immunosuppressants |
title_full_unstemmed | Neutropenic Enterocolitis in a Pediatric Heart Transplant Recipient on Multiple Immunosuppressants |
title_short | Neutropenic Enterocolitis in a Pediatric Heart Transplant Recipient on Multiple Immunosuppressants |
title_sort | neutropenic enterocolitis in a pediatric heart transplant recipient on multiple immunosuppressants |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964482/ https://www.ncbi.nlm.nih.gov/pubmed/29854547 http://dx.doi.org/10.1155/2018/3264921 |
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