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White Blood Cell and Granulocyte Counts Are Independent Predictive Factors for Prognosis of Advanced Pancreatic Caner
BACKGROUND: Pancreatic cancer is associated with high death rates and limited therapeutic options, with no effective predictive factors being available for prognosis at present. In this study, we evaluate the value of using blood test results for pancreatic cancer prognosis. METHOD: The records of 2...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964577/ https://www.ncbi.nlm.nih.gov/pubmed/29853866 http://dx.doi.org/10.1155/2018/8096234 |
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author | Feng, Lanyun Gu, Shihui Wang, Peng Chen, Hao Chen, Zhen Meng, Zhiqiang Liu, Luming |
author_facet | Feng, Lanyun Gu, Shihui Wang, Peng Chen, Hao Chen, Zhen Meng, Zhiqiang Liu, Luming |
author_sort | Feng, Lanyun |
collection | PubMed |
description | BACKGROUND: Pancreatic cancer is associated with high death rates and limited therapeutic options, with no effective predictive factors being available for prognosis at present. In this study, we evaluate the value of using blood test results for pancreatic cancer prognosis. METHOD: The records of 214 pancreatic cancer patients were reviewed. Blood test results for white blood cell (WBC), granulocyte, neutrophil, lymphocyte, platelet count, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) were dichotomized on the basis of median values. This was followed by univariate and multivariate analyses between groups. RESULTS: Patients with pretreatment values in the range WBC ≥ 5.8 × 10(9)/L, granulocyte ≥ 3.7 × 10(9)/L, neutrophil ≥ 3.9 × 10(9)/L, lymphocyte < 1.4 × 10(9)/L, and NLR ≥ 2.8 showed significant correlations pointing to poorer overall survival. Multivariate analysis indicated that WBC ≥ 5.8 × 10(9)/L (HR = 1.808; 95% CI = 1.055–3.096; p = 0.031) and granulocyte ≥ 3.7 × 10(9)/L (HR = 7.346; 95% CI = 1.275–42.321; p = 0.026) can be taken to be independent prognostic factors for overall survival in pancreatic patients. CONCLUSION: Pretreatment values of WBC and granulocyte count were independent factors with poor prognosis ability with respect to pancreatic cancer. |
format | Online Article Text |
id | pubmed-5964577 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-59645772018-05-31 White Blood Cell and Granulocyte Counts Are Independent Predictive Factors for Prognosis of Advanced Pancreatic Caner Feng, Lanyun Gu, Shihui Wang, Peng Chen, Hao Chen, Zhen Meng, Zhiqiang Liu, Luming Gastroenterol Res Pract Research Article BACKGROUND: Pancreatic cancer is associated with high death rates and limited therapeutic options, with no effective predictive factors being available for prognosis at present. In this study, we evaluate the value of using blood test results for pancreatic cancer prognosis. METHOD: The records of 214 pancreatic cancer patients were reviewed. Blood test results for white blood cell (WBC), granulocyte, neutrophil, lymphocyte, platelet count, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) were dichotomized on the basis of median values. This was followed by univariate and multivariate analyses between groups. RESULTS: Patients with pretreatment values in the range WBC ≥ 5.8 × 10(9)/L, granulocyte ≥ 3.7 × 10(9)/L, neutrophil ≥ 3.9 × 10(9)/L, lymphocyte < 1.4 × 10(9)/L, and NLR ≥ 2.8 showed significant correlations pointing to poorer overall survival. Multivariate analysis indicated that WBC ≥ 5.8 × 10(9)/L (HR = 1.808; 95% CI = 1.055–3.096; p = 0.031) and granulocyte ≥ 3.7 × 10(9)/L (HR = 7.346; 95% CI = 1.275–42.321; p = 0.026) can be taken to be independent prognostic factors for overall survival in pancreatic patients. CONCLUSION: Pretreatment values of WBC and granulocyte count were independent factors with poor prognosis ability with respect to pancreatic cancer. Hindawi 2018-05-08 /pmc/articles/PMC5964577/ /pubmed/29853866 http://dx.doi.org/10.1155/2018/8096234 Text en Copyright © 2018 Lanyun Feng et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Feng, Lanyun Gu, Shihui Wang, Peng Chen, Hao Chen, Zhen Meng, Zhiqiang Liu, Luming White Blood Cell and Granulocyte Counts Are Independent Predictive Factors for Prognosis of Advanced Pancreatic Caner |
title | White Blood Cell and Granulocyte Counts Are Independent Predictive Factors for Prognosis of Advanced Pancreatic Caner |
title_full | White Blood Cell and Granulocyte Counts Are Independent Predictive Factors for Prognosis of Advanced Pancreatic Caner |
title_fullStr | White Blood Cell and Granulocyte Counts Are Independent Predictive Factors for Prognosis of Advanced Pancreatic Caner |
title_full_unstemmed | White Blood Cell and Granulocyte Counts Are Independent Predictive Factors for Prognosis of Advanced Pancreatic Caner |
title_short | White Blood Cell and Granulocyte Counts Are Independent Predictive Factors for Prognosis of Advanced Pancreatic Caner |
title_sort | white blood cell and granulocyte counts are independent predictive factors for prognosis of advanced pancreatic caner |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964577/ https://www.ncbi.nlm.nih.gov/pubmed/29853866 http://dx.doi.org/10.1155/2018/8096234 |
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