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White Blood Cell and Granulocyte Counts Are Independent Predictive Factors for Prognosis of Advanced Pancreatic Caner

BACKGROUND: Pancreatic cancer is associated with high death rates and limited therapeutic options, with no effective predictive factors being available for prognosis at present. In this study, we evaluate the value of using blood test results for pancreatic cancer prognosis. METHOD: The records of 2...

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Autores principales: Feng, Lanyun, Gu, Shihui, Wang, Peng, Chen, Hao, Chen, Zhen, Meng, Zhiqiang, Liu, Luming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964577/
https://www.ncbi.nlm.nih.gov/pubmed/29853866
http://dx.doi.org/10.1155/2018/8096234
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author Feng, Lanyun
Gu, Shihui
Wang, Peng
Chen, Hao
Chen, Zhen
Meng, Zhiqiang
Liu, Luming
author_facet Feng, Lanyun
Gu, Shihui
Wang, Peng
Chen, Hao
Chen, Zhen
Meng, Zhiqiang
Liu, Luming
author_sort Feng, Lanyun
collection PubMed
description BACKGROUND: Pancreatic cancer is associated with high death rates and limited therapeutic options, with no effective predictive factors being available for prognosis at present. In this study, we evaluate the value of using blood test results for pancreatic cancer prognosis. METHOD: The records of 214 pancreatic cancer patients were reviewed. Blood test results for white blood cell (WBC), granulocyte, neutrophil, lymphocyte, platelet count, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) were dichotomized on the basis of median values. This was followed by univariate and multivariate analyses between groups. RESULTS: Patients with pretreatment values in the range WBC ≥ 5.8 × 10(9)/L, granulocyte ≥ 3.7 × 10(9)/L, neutrophil ≥ 3.9 × 10(9)/L, lymphocyte < 1.4 × 10(9)/L, and NLR ≥ 2.8 showed significant correlations pointing to poorer overall survival. Multivariate analysis indicated that WBC ≥ 5.8 × 10(9)/L (HR = 1.808; 95% CI = 1.055–3.096; p = 0.031) and granulocyte ≥ 3.7 × 10(9)/L (HR = 7.346; 95% CI = 1.275–42.321; p = 0.026) can be taken to be independent prognostic factors for overall survival in pancreatic patients. CONCLUSION: Pretreatment values of WBC and granulocyte count were independent factors with poor prognosis ability with respect to pancreatic cancer.
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spelling pubmed-59645772018-05-31 White Blood Cell and Granulocyte Counts Are Independent Predictive Factors for Prognosis of Advanced Pancreatic Caner Feng, Lanyun Gu, Shihui Wang, Peng Chen, Hao Chen, Zhen Meng, Zhiqiang Liu, Luming Gastroenterol Res Pract Research Article BACKGROUND: Pancreatic cancer is associated with high death rates and limited therapeutic options, with no effective predictive factors being available for prognosis at present. In this study, we evaluate the value of using blood test results for pancreatic cancer prognosis. METHOD: The records of 214 pancreatic cancer patients were reviewed. Blood test results for white blood cell (WBC), granulocyte, neutrophil, lymphocyte, platelet count, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) were dichotomized on the basis of median values. This was followed by univariate and multivariate analyses between groups. RESULTS: Patients with pretreatment values in the range WBC ≥ 5.8 × 10(9)/L, granulocyte ≥ 3.7 × 10(9)/L, neutrophil ≥ 3.9 × 10(9)/L, lymphocyte < 1.4 × 10(9)/L, and NLR ≥ 2.8 showed significant correlations pointing to poorer overall survival. Multivariate analysis indicated that WBC ≥ 5.8 × 10(9)/L (HR = 1.808; 95% CI = 1.055–3.096; p = 0.031) and granulocyte ≥ 3.7 × 10(9)/L (HR = 7.346; 95% CI = 1.275–42.321; p = 0.026) can be taken to be independent prognostic factors for overall survival in pancreatic patients. CONCLUSION: Pretreatment values of WBC and granulocyte count were independent factors with poor prognosis ability with respect to pancreatic cancer. Hindawi 2018-05-08 /pmc/articles/PMC5964577/ /pubmed/29853866 http://dx.doi.org/10.1155/2018/8096234 Text en Copyright © 2018 Lanyun Feng et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Feng, Lanyun
Gu, Shihui
Wang, Peng
Chen, Hao
Chen, Zhen
Meng, Zhiqiang
Liu, Luming
White Blood Cell and Granulocyte Counts Are Independent Predictive Factors for Prognosis of Advanced Pancreatic Caner
title White Blood Cell and Granulocyte Counts Are Independent Predictive Factors for Prognosis of Advanced Pancreatic Caner
title_full White Blood Cell and Granulocyte Counts Are Independent Predictive Factors for Prognosis of Advanced Pancreatic Caner
title_fullStr White Blood Cell and Granulocyte Counts Are Independent Predictive Factors for Prognosis of Advanced Pancreatic Caner
title_full_unstemmed White Blood Cell and Granulocyte Counts Are Independent Predictive Factors for Prognosis of Advanced Pancreatic Caner
title_short White Blood Cell and Granulocyte Counts Are Independent Predictive Factors for Prognosis of Advanced Pancreatic Caner
title_sort white blood cell and granulocyte counts are independent predictive factors for prognosis of advanced pancreatic caner
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964577/
https://www.ncbi.nlm.nih.gov/pubmed/29853866
http://dx.doi.org/10.1155/2018/8096234
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