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A RET-supported logic gate combinatorial library to enable modeling and implementation of intelligent logic functions

Boolean logic gates integrate multiple digital inputs into a digital output. Among these, logic gates based on nucleic acids have attracted a great deal of attention due to the prospect of controlling living systems in the way we control electronic computers. Herein, by employing Thioflavin T (ThT)...

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Autores principales: Gao, Ru-Ru, Shi, Shuo, Zhu, Ying, Huang, Hai-Liang, Yao, Tian-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964972/
https://www.ncbi.nlm.nih.gov/pubmed/29899907
http://dx.doi.org/10.1039/c5sc03570h
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author Gao, Ru-Ru
Shi, Shuo
Zhu, Ying
Huang, Hai-Liang
Yao, Tian-Ming
author_facet Gao, Ru-Ru
Shi, Shuo
Zhu, Ying
Huang, Hai-Liang
Yao, Tian-Ming
author_sort Gao, Ru-Ru
collection PubMed
description Boolean logic gates integrate multiple digital inputs into a digital output. Among these, logic gates based on nucleic acids have attracted a great deal of attention due to the prospect of controlling living systems in the way we control electronic computers. Herein, by employing Thioflavin T (ThT) as a signal transducer, we integrated multiple components based on RET (a type of proto-oncogene) into a logic gate combinatorial library, including basic logic gates (NOR, INHIBIT, IMPLICATION), a single three-input NOR gate, and combinatorial gates (INHIBIT–OR, NOT–AND–NOR). In this library, gates were connected in series where the output of the previous gate was the input for the next gate. Subsequently, by taking advantage of the library, some intelligent logic functions were realized. Expectedly, a biocomputing keypad-lock security system was designed by sequential logic operations. Moreover, a parity checker which can identify even numbers and odd numbers from natural numbers was established successfully. This work helps elucidate the design rules by which simple logic can be harnessed to produce diverse and complex calculations by rewiring communication between different gates. Together, our system may serve as a promising proof of principle that demonstrates increased computational complexity by linking multiple logic gates together.
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spelling pubmed-59649722018-06-13 A RET-supported logic gate combinatorial library to enable modeling and implementation of intelligent logic functions Gao, Ru-Ru Shi, Shuo Zhu, Ying Huang, Hai-Liang Yao, Tian-Ming Chem Sci Chemistry Boolean logic gates integrate multiple digital inputs into a digital output. Among these, logic gates based on nucleic acids have attracted a great deal of attention due to the prospect of controlling living systems in the way we control electronic computers. Herein, by employing Thioflavin T (ThT) as a signal transducer, we integrated multiple components based on RET (a type of proto-oncogene) into a logic gate combinatorial library, including basic logic gates (NOR, INHIBIT, IMPLICATION), a single three-input NOR gate, and combinatorial gates (INHIBIT–OR, NOT–AND–NOR). In this library, gates were connected in series where the output of the previous gate was the input for the next gate. Subsequently, by taking advantage of the library, some intelligent logic functions were realized. Expectedly, a biocomputing keypad-lock security system was designed by sequential logic operations. Moreover, a parity checker which can identify even numbers and odd numbers from natural numbers was established successfully. This work helps elucidate the design rules by which simple logic can be harnessed to produce diverse and complex calculations by rewiring communication between different gates. Together, our system may serve as a promising proof of principle that demonstrates increased computational complexity by linking multiple logic gates together. Royal Society of Chemistry 2016-03-01 2015-11-23 /pmc/articles/PMC5964972/ /pubmed/29899907 http://dx.doi.org/10.1039/c5sc03570h Text en This journal is © The Royal Society of Chemistry 2016 http://creativecommons.org/licenses/by-nc/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported Licence (CC BY-NC 3.0)
spellingShingle Chemistry
Gao, Ru-Ru
Shi, Shuo
Zhu, Ying
Huang, Hai-Liang
Yao, Tian-Ming
A RET-supported logic gate combinatorial library to enable modeling and implementation of intelligent logic functions
title A RET-supported logic gate combinatorial library to enable modeling and implementation of intelligent logic functions
title_full A RET-supported logic gate combinatorial library to enable modeling and implementation of intelligent logic functions
title_fullStr A RET-supported logic gate combinatorial library to enable modeling and implementation of intelligent logic functions
title_full_unstemmed A RET-supported logic gate combinatorial library to enable modeling and implementation of intelligent logic functions
title_short A RET-supported logic gate combinatorial library to enable modeling and implementation of intelligent logic functions
title_sort ret-supported logic gate combinatorial library to enable modeling and implementation of intelligent logic functions
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964972/
https://www.ncbi.nlm.nih.gov/pubmed/29899907
http://dx.doi.org/10.1039/c5sc03570h
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