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A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells
The real-time monitoring of reactive oxygen species (ROS, particularly singlet oxygen) generation during photodynamic therapy is a great challenge due to the extremely short half-life and small radius of action. To tackle this issue, we herein report a bioprobe composed of a red emissive photosensit...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royal Society of Chemistry
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965248/ https://www.ncbi.nlm.nih.gov/pubmed/29899908 http://dx.doi.org/10.1039/c5sc03583j |
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author | Yuan, Youyong Zhang, Chong-Jing Xu, Shidang Liu, Bin |
author_facet | Yuan, Youyong Zhang, Chong-Jing Xu, Shidang Liu, Bin |
author_sort | Yuan, Youyong |
collection | PubMed |
description | The real-time monitoring of reactive oxygen species (ROS, particularly singlet oxygen) generation during photodynamic therapy is a great challenge due to the extremely short half-life and small radius of action. To tackle this issue, we herein report a bioprobe composed of a red emissive photosensitizer (PS) with aggregation-induced emission (AIE) characteristics and a fluorogenic green emissive rhodol dye conjugated via a singlet oxygen cleavable aminoacrylate (AA) linker. The probe emits red fluorescence in water, and the red emissive PS can be used for probe self-tracking. Upon image-guided light irradiation, the generated singlet oxygen cleaves the AA linker to yield green fluorescence turn-on of rhodol, which offers real-time and in situ monitoring of singlet oxygen generation during photodynamic ablation of cancer cells, providing a strategy for the early evaluation of the therapeutic effect. |
format | Online Article Text |
id | pubmed-5965248 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-59652482018-06-13 A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells Yuan, Youyong Zhang, Chong-Jing Xu, Shidang Liu, Bin Chem Sci Chemistry The real-time monitoring of reactive oxygen species (ROS, particularly singlet oxygen) generation during photodynamic therapy is a great challenge due to the extremely short half-life and small radius of action. To tackle this issue, we herein report a bioprobe composed of a red emissive photosensitizer (PS) with aggregation-induced emission (AIE) characteristics and a fluorogenic green emissive rhodol dye conjugated via a singlet oxygen cleavable aminoacrylate (AA) linker. The probe emits red fluorescence in water, and the red emissive PS can be used for probe self-tracking. Upon image-guided light irradiation, the generated singlet oxygen cleaves the AA linker to yield green fluorescence turn-on of rhodol, which offers real-time and in situ monitoring of singlet oxygen generation during photodynamic ablation of cancer cells, providing a strategy for the early evaluation of the therapeutic effect. Royal Society of Chemistry 2016-03-01 2015-11-23 /pmc/articles/PMC5965248/ /pubmed/29899908 http://dx.doi.org/10.1039/c5sc03583j Text en This journal is © The Royal Society of Chemistry 2016 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0) |
spellingShingle | Chemistry Yuan, Youyong Zhang, Chong-Jing Xu, Shidang Liu, Bin A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells |
title | A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells
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title_full | A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells
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title_fullStr | A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells
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title_full_unstemmed | A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells
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title_short | A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells
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title_sort | self-reporting aie probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965248/ https://www.ncbi.nlm.nih.gov/pubmed/29899908 http://dx.doi.org/10.1039/c5sc03583j |
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