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A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells

The real-time monitoring of reactive oxygen species (ROS, particularly singlet oxygen) generation during photodynamic therapy is a great challenge due to the extremely short half-life and small radius of action. To tackle this issue, we herein report a bioprobe composed of a red emissive photosensit...

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Detalles Bibliográficos
Autores principales: Yuan, Youyong, Zhang, Chong-Jing, Xu, Shidang, Liu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965248/
https://www.ncbi.nlm.nih.gov/pubmed/29899908
http://dx.doi.org/10.1039/c5sc03583j
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author Yuan, Youyong
Zhang, Chong-Jing
Xu, Shidang
Liu, Bin
author_facet Yuan, Youyong
Zhang, Chong-Jing
Xu, Shidang
Liu, Bin
author_sort Yuan, Youyong
collection PubMed
description The real-time monitoring of reactive oxygen species (ROS, particularly singlet oxygen) generation during photodynamic therapy is a great challenge due to the extremely short half-life and small radius of action. To tackle this issue, we herein report a bioprobe composed of a red emissive photosensitizer (PS) with aggregation-induced emission (AIE) characteristics and a fluorogenic green emissive rhodol dye conjugated via a singlet oxygen cleavable aminoacrylate (AA) linker. The probe emits red fluorescence in water, and the red emissive PS can be used for probe self-tracking. Upon image-guided light irradiation, the generated singlet oxygen cleaves the AA linker to yield green fluorescence turn-on of rhodol, which offers real-time and in situ monitoring of singlet oxygen generation during photodynamic ablation of cancer cells, providing a strategy for the early evaluation of the therapeutic effect.
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spelling pubmed-59652482018-06-13 A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells Yuan, Youyong Zhang, Chong-Jing Xu, Shidang Liu, Bin Chem Sci Chemistry The real-time monitoring of reactive oxygen species (ROS, particularly singlet oxygen) generation during photodynamic therapy is a great challenge due to the extremely short half-life and small radius of action. To tackle this issue, we herein report a bioprobe composed of a red emissive photosensitizer (PS) with aggregation-induced emission (AIE) characteristics and a fluorogenic green emissive rhodol dye conjugated via a singlet oxygen cleavable aminoacrylate (AA) linker. The probe emits red fluorescence in water, and the red emissive PS can be used for probe self-tracking. Upon image-guided light irradiation, the generated singlet oxygen cleaves the AA linker to yield green fluorescence turn-on of rhodol, which offers real-time and in situ monitoring of singlet oxygen generation during photodynamic ablation of cancer cells, providing a strategy for the early evaluation of the therapeutic effect. Royal Society of Chemistry 2016-03-01 2015-11-23 /pmc/articles/PMC5965248/ /pubmed/29899908 http://dx.doi.org/10.1039/c5sc03583j Text en This journal is © The Royal Society of Chemistry 2016 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)
spellingShingle Chemistry
Yuan, Youyong
Zhang, Chong-Jing
Xu, Shidang
Liu, Bin
A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells
title A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells
title_full A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells
title_fullStr A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells
title_full_unstemmed A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells
title_short A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells
title_sort self-reporting aie probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965248/
https://www.ncbi.nlm.nih.gov/pubmed/29899908
http://dx.doi.org/10.1039/c5sc03583j
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