Cargando…
Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation
OBJECTIVES: Delayed sleep phase syndrome (DSPS) is a chronic dysfunction of circadian rhythm of the subject that impairs functioning in social, occupational, or other spheres. High rate of depression is found among DSPS patients. Aripiprazole (APZ), a second-generation antipsychotic, is effective in...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965391/ https://www.ncbi.nlm.nih.gov/pubmed/29849459 http://dx.doi.org/10.2147/NDT.S158865 |
_version_ | 1783325349543673856 |
---|---|
author | Omori, Yuki Kanbayashi, Takashi Sagawa, Yohei Imanishi, Aya Tsutsui, Ko Takahashi, Yuya Takeshima, Masahiro Takaki, Manabu Nishino, Seiji Shimizu, Tetsuo |
author_facet | Omori, Yuki Kanbayashi, Takashi Sagawa, Yohei Imanishi, Aya Tsutsui, Ko Takahashi, Yuya Takeshima, Masahiro Takaki, Manabu Nishino, Seiji Shimizu, Tetsuo |
author_sort | Omori, Yuki |
collection | PubMed |
description | OBJECTIVES: Delayed sleep phase syndrome (DSPS) is a chronic dysfunction of circadian rhythm of the subject that impairs functioning in social, occupational, or other spheres. High rate of depression is found among DSPS patients. Aripiprazole (APZ), a second-generation antipsychotic, is effective in treatment of depression as well as schizophrenia. Recently, few case reports show the effectiveness of APZ in treating DSPS and non-24-hour sleep–wake rhythm disorder. Therefore, we tried to treat DSPS with depression using APZ. METHODS: Twelve subjects (including four women) aged 19–64 years were included. The subjects were prescribed initially 0.5–3 mg of APZ once a day with subsequent dose adjustments. RESULTS: Sleep onset, midpoint of sleep, and sleep offset were significantly advanced by 1.1, 1.8, and 2.5 hours, respectively. Unexpectedly, sleep duration became significantly shorter by 1.3 hours after treatment. Their depressive moods showed an unremarkable change. CONCLUSION: Low dose of APZ advanced the sleep rhythm and reduced nocturnal sleep time in the subjects with DSPS. Since it is not easy for physicians to treat prolonged sleep duration often associated with DSPS, this medication would become a new therapeutic option for these patients. |
format | Online Article Text |
id | pubmed-5965391 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-59653912018-05-30 Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation Omori, Yuki Kanbayashi, Takashi Sagawa, Yohei Imanishi, Aya Tsutsui, Ko Takahashi, Yuya Takeshima, Masahiro Takaki, Manabu Nishino, Seiji Shimizu, Tetsuo Neuropsychiatr Dis Treat Clinical Trial Report OBJECTIVES: Delayed sleep phase syndrome (DSPS) is a chronic dysfunction of circadian rhythm of the subject that impairs functioning in social, occupational, or other spheres. High rate of depression is found among DSPS patients. Aripiprazole (APZ), a second-generation antipsychotic, is effective in treatment of depression as well as schizophrenia. Recently, few case reports show the effectiveness of APZ in treating DSPS and non-24-hour sleep–wake rhythm disorder. Therefore, we tried to treat DSPS with depression using APZ. METHODS: Twelve subjects (including four women) aged 19–64 years were included. The subjects were prescribed initially 0.5–3 mg of APZ once a day with subsequent dose adjustments. RESULTS: Sleep onset, midpoint of sleep, and sleep offset were significantly advanced by 1.1, 1.8, and 2.5 hours, respectively. Unexpectedly, sleep duration became significantly shorter by 1.3 hours after treatment. Their depressive moods showed an unremarkable change. CONCLUSION: Low dose of APZ advanced the sleep rhythm and reduced nocturnal sleep time in the subjects with DSPS. Since it is not easy for physicians to treat prolonged sleep duration often associated with DSPS, this medication would become a new therapeutic option for these patients. Dove Medical Press 2018-05-18 /pmc/articles/PMC5965391/ /pubmed/29849459 http://dx.doi.org/10.2147/NDT.S158865 Text en © 2018 Omori et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Clinical Trial Report Omori, Yuki Kanbayashi, Takashi Sagawa, Yohei Imanishi, Aya Tsutsui, Ko Takahashi, Yuya Takeshima, Masahiro Takaki, Manabu Nishino, Seiji Shimizu, Tetsuo Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation |
title | Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation |
title_full | Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation |
title_fullStr | Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation |
title_full_unstemmed | Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation |
title_short | Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation |
title_sort | low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation |
topic | Clinical Trial Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965391/ https://www.ncbi.nlm.nih.gov/pubmed/29849459 http://dx.doi.org/10.2147/NDT.S158865 |
work_keys_str_mv | AT omoriyuki lowdoseofaripiprazoleadvancedsleeprhythmandreducednocturnalsleeptimeinthepatientswithdelayedsleepphasesyndromeanopenlabeledclinicalobservation AT kanbayashitakashi lowdoseofaripiprazoleadvancedsleeprhythmandreducednocturnalsleeptimeinthepatientswithdelayedsleepphasesyndromeanopenlabeledclinicalobservation AT sagawayohei lowdoseofaripiprazoleadvancedsleeprhythmandreducednocturnalsleeptimeinthepatientswithdelayedsleepphasesyndromeanopenlabeledclinicalobservation AT imanishiaya lowdoseofaripiprazoleadvancedsleeprhythmandreducednocturnalsleeptimeinthepatientswithdelayedsleepphasesyndromeanopenlabeledclinicalobservation AT tsutsuiko lowdoseofaripiprazoleadvancedsleeprhythmandreducednocturnalsleeptimeinthepatientswithdelayedsleepphasesyndromeanopenlabeledclinicalobservation AT takahashiyuya lowdoseofaripiprazoleadvancedsleeprhythmandreducednocturnalsleeptimeinthepatientswithdelayedsleepphasesyndromeanopenlabeledclinicalobservation AT takeshimamasahiro lowdoseofaripiprazoleadvancedsleeprhythmandreducednocturnalsleeptimeinthepatientswithdelayedsleepphasesyndromeanopenlabeledclinicalobservation AT takakimanabu lowdoseofaripiprazoleadvancedsleeprhythmandreducednocturnalsleeptimeinthepatientswithdelayedsleepphasesyndromeanopenlabeledclinicalobservation AT nishinoseiji lowdoseofaripiprazoleadvancedsleeprhythmandreducednocturnalsleeptimeinthepatientswithdelayedsleepphasesyndromeanopenlabeledclinicalobservation AT shimizutetsuo lowdoseofaripiprazoleadvancedsleeprhythmandreducednocturnalsleeptimeinthepatientswithdelayedsleepphasesyndromeanopenlabeledclinicalobservation |