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Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrP(C)) in Alzheimer’s disease

The cellular prion protein (PrP(C)) is implicated in neuroprotective signaling and neurotoxic pathways in both prion diseases and Alzheimer’s disease (AD). Specifically, the intrinsically disordered N-terminal domain (N-PrP) has been shown to interact with neurotoxic ligands, such as Aβ and Scrapie...

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Detalles Bibliográficos
Autores principales:	Ulbrich, Sarah, Janning, Petra, Seidel, Ralf, Matschke, Jakob, Gonsberg, Anika, Jung, Sebastian, Glatzel, Markus, Engelhard, Martin, Winklhofer, Konstanze F., Tatzelt, Jörg
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965872/ https://www.ncbi.nlm.nih.gov/pubmed/29791485 http://dx.doi.org/10.1371/journal.pone.0197659

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