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CPR-IR is an insulin resistance index that is minimally affected by hepatic insulin clearance—A preliminary research

BACKGROUND: Increased hepatic insulin clearance (HIC) is important in the pathophysiology of type 2 diabetes mellitus (T2DM). The aim of this study is to analyze an effective insulin resistance (IR) index that is minimally affected by HIC. METHODS: Our study involved 20 participants with T2DM and 21...

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Autores principales: Okura, Tsuyoshi, Nakamura, Risa, Fujioka, Yohei, Kawamoto-Kitao, Sonoko, Ito, Yuichi, Matsumoto, Kazuhisa, Shoji, Kyoko, Sumi, Keisuke, Matsuzawa, Kazuhiko, Izawa, Shoichiro, Ueta, Etsuko, Kato, Masahiko, Imamura, Takeshi, Taniguchi, Shin-ichi, Yamamoto, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965889/
https://www.ncbi.nlm.nih.gov/pubmed/29791512
http://dx.doi.org/10.1371/journal.pone.0197663
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author Okura, Tsuyoshi
Nakamura, Risa
Fujioka, Yohei
Kawamoto-Kitao, Sonoko
Ito, Yuichi
Matsumoto, Kazuhisa
Shoji, Kyoko
Sumi, Keisuke
Matsuzawa, Kazuhiko
Izawa, Shoichiro
Ueta, Etsuko
Kato, Masahiko
Imamura, Takeshi
Taniguchi, Shin-ichi
Yamamoto, Kazuhiro
author_facet Okura, Tsuyoshi
Nakamura, Risa
Fujioka, Yohei
Kawamoto-Kitao, Sonoko
Ito, Yuichi
Matsumoto, Kazuhisa
Shoji, Kyoko
Sumi, Keisuke
Matsuzawa, Kazuhiko
Izawa, Shoichiro
Ueta, Etsuko
Kato, Masahiko
Imamura, Takeshi
Taniguchi, Shin-ichi
Yamamoto, Kazuhiro
author_sort Okura, Tsuyoshi
collection PubMed
description BACKGROUND: Increased hepatic insulin clearance (HIC) is important in the pathophysiology of type 2 diabetes mellitus (T2DM). The aim of this study is to analyze an effective insulin resistance (IR) index that is minimally affected by HIC. METHODS: Our study involved 20 participants with T2DM and 21 healthy participants without diabetes (Non-DM). Participants underwent a meal tolerance test from which plasma glucose, insulin and serum C-peptide immunoreactivity (CPR) were measured, and HOMA-IR and HIC were calculated. Participants then underwent a hyperinsulinemic-euglycemic clamp from which the glucose disposal rate (GDR) was measured. RESULTS: The index CPR-IR = 20/(fasting CPR × fasting plasma glucose) was correlated more strongly with GDR, than was HOMA-IR, and CPR-IR could be used to estimate GDR. In T2DM participants with HIC below the median, HOMA-IR and CPR-IR were equally well correlated with GDR. In T2DM with high HIC, CPR-IR correlated with GDR while HOMA-IR did not. In Non-DM, CPR-IR and HOMA-IR were equally well correlated with GDR regardless of HIC. The mean HIC value in T2DM was significantly higher than that of Non-DM. CONCLUSIONS: CPR-IR could be a simple and effective index of insulin resistance for patients with type 2 diabetes that is minimally affected by HIC.
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spelling pubmed-59658892018-06-02 CPR-IR is an insulin resistance index that is minimally affected by hepatic insulin clearance—A preliminary research Okura, Tsuyoshi Nakamura, Risa Fujioka, Yohei Kawamoto-Kitao, Sonoko Ito, Yuichi Matsumoto, Kazuhisa Shoji, Kyoko Sumi, Keisuke Matsuzawa, Kazuhiko Izawa, Shoichiro Ueta, Etsuko Kato, Masahiko Imamura, Takeshi Taniguchi, Shin-ichi Yamamoto, Kazuhiro PLoS One Research Article BACKGROUND: Increased hepatic insulin clearance (HIC) is important in the pathophysiology of type 2 diabetes mellitus (T2DM). The aim of this study is to analyze an effective insulin resistance (IR) index that is minimally affected by HIC. METHODS: Our study involved 20 participants with T2DM and 21 healthy participants without diabetes (Non-DM). Participants underwent a meal tolerance test from which plasma glucose, insulin and serum C-peptide immunoreactivity (CPR) were measured, and HOMA-IR and HIC were calculated. Participants then underwent a hyperinsulinemic-euglycemic clamp from which the glucose disposal rate (GDR) was measured. RESULTS: The index CPR-IR = 20/(fasting CPR × fasting plasma glucose) was correlated more strongly with GDR, than was HOMA-IR, and CPR-IR could be used to estimate GDR. In T2DM participants with HIC below the median, HOMA-IR and CPR-IR were equally well correlated with GDR. In T2DM with high HIC, CPR-IR correlated with GDR while HOMA-IR did not. In Non-DM, CPR-IR and HOMA-IR were equally well correlated with GDR regardless of HIC. The mean HIC value in T2DM was significantly higher than that of Non-DM. CONCLUSIONS: CPR-IR could be a simple and effective index of insulin resistance for patients with type 2 diabetes that is minimally affected by HIC. Public Library of Science 2018-05-23 /pmc/articles/PMC5965889/ /pubmed/29791512 http://dx.doi.org/10.1371/journal.pone.0197663 Text en © 2018 Okura et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Okura, Tsuyoshi
Nakamura, Risa
Fujioka, Yohei
Kawamoto-Kitao, Sonoko
Ito, Yuichi
Matsumoto, Kazuhisa
Shoji, Kyoko
Sumi, Keisuke
Matsuzawa, Kazuhiko
Izawa, Shoichiro
Ueta, Etsuko
Kato, Masahiko
Imamura, Takeshi
Taniguchi, Shin-ichi
Yamamoto, Kazuhiro
CPR-IR is an insulin resistance index that is minimally affected by hepatic insulin clearance—A preliminary research
title CPR-IR is an insulin resistance index that is minimally affected by hepatic insulin clearance—A preliminary research
title_full CPR-IR is an insulin resistance index that is minimally affected by hepatic insulin clearance—A preliminary research
title_fullStr CPR-IR is an insulin resistance index that is minimally affected by hepatic insulin clearance—A preliminary research
title_full_unstemmed CPR-IR is an insulin resistance index that is minimally affected by hepatic insulin clearance—A preliminary research
title_short CPR-IR is an insulin resistance index that is minimally affected by hepatic insulin clearance—A preliminary research
title_sort cpr-ir is an insulin resistance index that is minimally affected by hepatic insulin clearance—a preliminary research
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965889/
https://www.ncbi.nlm.nih.gov/pubmed/29791512
http://dx.doi.org/10.1371/journal.pone.0197663
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