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Single-molecule analysis reveals the mechanism of transcription activation in M. tuberculosis

The σ subunit of bacterial RNA polymerase (RNAP) controls recognition of the −10 and −35 promoter elements during transcription initiation. Free σ adopts a “closed,” or inactive, conformation incompatible with promoter binding. The conventional two-state model of σ activation proposes that binding t...

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Detalles Bibliográficos
Autores principales:	Vishwakarma, Rishi Kishore, Cao, Anne-Marinette, Morichaud, Zakia, Perumal, Ayyappasamy Sudalaiyadum, Margeat, Emmanuel, Brodolin, Konstantin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966222/ https://www.ncbi.nlm.nih.gov/pubmed/29806016 http://dx.doi.org/10.1126/sciadv.aao5498

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