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Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1
Piezo proteins are transmembrane ion channels which transduce many forms of mechanical stimuli into electrochemical signals. Their pore, formed by the assembly of three identical subunits, opens by an unknown mechanism. Here, to probe this mechanism, we investigate the interaction of Piezo1 with the...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966384/ https://www.ncbi.nlm.nih.gov/pubmed/29795280 http://dx.doi.org/10.1038/s41467-018-04405-3 |