Dysregulation of the MiR-449b target TGFBI alters the TGFβ pathway to induce cisplatin resistance in nasopharyngeal carcinoma

Despite the improvement in locoregional control of nasopharyngeal carcinoma (NPC), distant metastasis (DM), and chemoresistance persist as major causes of mortality. This study identified a novel role for miR-449b, an overexpressed gene in a validated four-miRNA signature for NPC DM, leading to chem...

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Detalles Bibliográficos
Autores principales: Bissey, Pierre-Antoine, Law, Jacqueline H., Bruce, Jeff P., Shi, Wei, Renoult, Aline, Chua, Melvin L. K., Yip, Kenneth W., Liu, Fei-Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966388/
https://www.ncbi.nlm.nih.gov/pubmed/29795279
http://dx.doi.org/10.1038/s41389-018-0050-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966388/
https://www.ncbi.nlm.nih.gov/pubmed/29795279
http://dx.doi.org/10.1038/s41389-018-0050-x

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