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Longitudinal and cross-sectional investigations of long-term potentiation-like cortical plasticity in bipolar disorder type II and healthy individuals

Visual evoked potential (VEP) plasticity is a promising assay for noninvasive examination of long-term potentiation (LTP)-like synaptic processes in the cerebral cortex. We conducted longitudinal and cross-sectional investigations of VEP plasticity in controls and individuals with bipolar disorder (...

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Autores principales: Zak, Nathalia, Moberget, Torgeir, Bøen, Erlend, Boye, Birgitte, Waage, Trine R., Dietrichs, Espen, Harkestad, Nina, Malt, Ulrik F., Westlye, Lars T., Andreassen, Ole A., Andersson, Stein, Elvsåshagen, Torbjørn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966393/
https://www.ncbi.nlm.nih.gov/pubmed/29795193
http://dx.doi.org/10.1038/s41398-018-0151-5
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author Zak, Nathalia
Moberget, Torgeir
Bøen, Erlend
Boye, Birgitte
Waage, Trine R.
Dietrichs, Espen
Harkestad, Nina
Malt, Ulrik F.
Westlye, Lars T.
Andreassen, Ole A.
Andersson, Stein
Elvsåshagen, Torbjørn
author_facet Zak, Nathalia
Moberget, Torgeir
Bøen, Erlend
Boye, Birgitte
Waage, Trine R.
Dietrichs, Espen
Harkestad, Nina
Malt, Ulrik F.
Westlye, Lars T.
Andreassen, Ole A.
Andersson, Stein
Elvsåshagen, Torbjørn
author_sort Zak, Nathalia
collection PubMed
description Visual evoked potential (VEP) plasticity is a promising assay for noninvasive examination of long-term potentiation (LTP)-like synaptic processes in the cerebral cortex. We conducted longitudinal and cross-sectional investigations of VEP plasticity in controls and individuals with bipolar disorder (BD) type II. VEP plasticity was assessed at baseline, as described previously (Elvsåshagen et al. Biol Psychiatry 2012), and 2.2 years later, at follow-up. The longitudinal sample with VEP data from both time points comprised 29 controls and 16 patients. VEP data were available from 13 additional patients at follow-up (total n = 58). VEPs were evoked by checkerboard reversals in two premodulation blocks before and six blocks after a plasticity-inducing block of prolonged (10 min) visual stimulation. VEP plasticity was computed by subtracting premodulation VEP amplitudes from postmodulation amplitudes. Saliva samples for cortisol analysis were collected immediately after awakening in the morning, 30 min later, and at 12:30 PM, at follow-up. We found reduced VEP plasticity in BD type II, that impaired plasticity was present in the euthymic phases of the illness, and that VEP plasticity correlated negatively with depression severity. There was a positive association between VEP plasticity and saliva cortisol in controls, possibly reflecting an inverted U-shaped relationship between cortisol and synaptic plasticity. VEP plasticity exhibited moderate temporal stability over a period of 2.2 years. The present study provides additional evidence for impaired LTP-like cortical plasticity in BD type II. VEP plasticity is an accessible method, which may help elucidate the pathophysiological and clinical significance of synaptic dysfunction in psychiatric disorders.
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spelling pubmed-59663932018-05-24 Longitudinal and cross-sectional investigations of long-term potentiation-like cortical plasticity in bipolar disorder type II and healthy individuals Zak, Nathalia Moberget, Torgeir Bøen, Erlend Boye, Birgitte Waage, Trine R. Dietrichs, Espen Harkestad, Nina Malt, Ulrik F. Westlye, Lars T. Andreassen, Ole A. Andersson, Stein Elvsåshagen, Torbjørn Transl Psychiatry Article Visual evoked potential (VEP) plasticity is a promising assay for noninvasive examination of long-term potentiation (LTP)-like synaptic processes in the cerebral cortex. We conducted longitudinal and cross-sectional investigations of VEP plasticity in controls and individuals with bipolar disorder (BD) type II. VEP plasticity was assessed at baseline, as described previously (Elvsåshagen et al. Biol Psychiatry 2012), and 2.2 years later, at follow-up. The longitudinal sample with VEP data from both time points comprised 29 controls and 16 patients. VEP data were available from 13 additional patients at follow-up (total n = 58). VEPs were evoked by checkerboard reversals in two premodulation blocks before and six blocks after a plasticity-inducing block of prolonged (10 min) visual stimulation. VEP plasticity was computed by subtracting premodulation VEP amplitudes from postmodulation amplitudes. Saliva samples for cortisol analysis were collected immediately after awakening in the morning, 30 min later, and at 12:30 PM, at follow-up. We found reduced VEP plasticity in BD type II, that impaired plasticity was present in the euthymic phases of the illness, and that VEP plasticity correlated negatively with depression severity. There was a positive association between VEP plasticity and saliva cortisol in controls, possibly reflecting an inverted U-shaped relationship between cortisol and synaptic plasticity. VEP plasticity exhibited moderate temporal stability over a period of 2.2 years. The present study provides additional evidence for impaired LTP-like cortical plasticity in BD type II. VEP plasticity is an accessible method, which may help elucidate the pathophysiological and clinical significance of synaptic dysfunction in psychiatric disorders. Nature Publishing Group UK 2018-05-24 /pmc/articles/PMC5966393/ /pubmed/29795193 http://dx.doi.org/10.1038/s41398-018-0151-5 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Zak, Nathalia
Moberget, Torgeir
Bøen, Erlend
Boye, Birgitte
Waage, Trine R.
Dietrichs, Espen
Harkestad, Nina
Malt, Ulrik F.
Westlye, Lars T.
Andreassen, Ole A.
Andersson, Stein
Elvsåshagen, Torbjørn
Longitudinal and cross-sectional investigations of long-term potentiation-like cortical plasticity in bipolar disorder type II and healthy individuals
title Longitudinal and cross-sectional investigations of long-term potentiation-like cortical plasticity in bipolar disorder type II and healthy individuals
title_full Longitudinal and cross-sectional investigations of long-term potentiation-like cortical plasticity in bipolar disorder type II and healthy individuals
title_fullStr Longitudinal and cross-sectional investigations of long-term potentiation-like cortical plasticity in bipolar disorder type II and healthy individuals
title_full_unstemmed Longitudinal and cross-sectional investigations of long-term potentiation-like cortical plasticity in bipolar disorder type II and healthy individuals
title_short Longitudinal and cross-sectional investigations of long-term potentiation-like cortical plasticity in bipolar disorder type II and healthy individuals
title_sort longitudinal and cross-sectional investigations of long-term potentiation-like cortical plasticity in bipolar disorder type ii and healthy individuals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966393/
https://www.ncbi.nlm.nih.gov/pubmed/29795193
http://dx.doi.org/10.1038/s41398-018-0151-5
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