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HDV infection rates in northern Vietnam
Hepatitis D caused by the hepatitis delta virus (HDV) is a serious health problem in many regions of the world. A total of 546 HBV-infected patients were enrolled from 2013 to 2015 and classified clinically into the subgroups of chronic hepatitis B (CHB, n = 191), liver cirrhosis (LC, n = 147) and h...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966401/ https://www.ncbi.nlm.nih.gov/pubmed/29795302 http://dx.doi.org/10.1038/s41598-018-26446-w |
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author | Binh, Mai Thanh Hoan, Nghiem Xuan Van Tong, Hoang Giang, Dao Phuong Sy, Bui Tien Toan, Nguyen Linh Song, Le Huu Bang, Mai Hong Wedemeyer, Heiner Meyer, Christian G. Kremsner, Peter G. Bock, C.-Thomas Velavan, Thirumalaisamy P. |
author_facet | Binh, Mai Thanh Hoan, Nghiem Xuan Van Tong, Hoang Giang, Dao Phuong Sy, Bui Tien Toan, Nguyen Linh Song, Le Huu Bang, Mai Hong Wedemeyer, Heiner Meyer, Christian G. Kremsner, Peter G. Bock, C.-Thomas Velavan, Thirumalaisamy P. |
author_sort | Binh, Mai Thanh |
collection | PubMed |
description | Hepatitis D caused by the hepatitis delta virus (HDV) is a serious health problem in many regions of the world. A total of 546 HBV-infected patients were enrolled from 2013 to 2015 and classified clinically into the subgroups of chronic hepatitis B (CHB, n = 191), liver cirrhosis (LC, n = 147) and hepatocellular carcinoma (HCC, n = 208). The patients were screened for HDV-RNA by nested PCR assays. HDV genotypes were assessed by direct sequencing, followed by phylogenetic analysis. HDV-RNA was identified in 13% (71/546) of HBV-infected patients. The highest HDV prevalence was found in the LC group (19.7%), followed by the HCC (12%) and CHB (8.9%) groups (P = 0.017). HDV/HBV coinfections were significantly associated with a rather unfavourable clinical outcome, in particular with LC development compared to HBV monoinfection. Phylogenetic analyses indicated that the genotype HDV1 was, with a prevalence of 91%, by far the most common genotype in Vietnam, followed by HDV2 with 9%. Other HDV genotypes were not observed. In accordance with previous data obtained a decade ago, our results confirm a continuing high prevalence of HDV infection in hepatitis B patients in northern Vietnam with the HDV1 genotype still being the predominant genotype. HDV nucleic acid testing to minimize the associated risk should be considered. |
format | Online Article Text |
id | pubmed-5966401 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-59664012018-05-24 HDV infection rates in northern Vietnam Binh, Mai Thanh Hoan, Nghiem Xuan Van Tong, Hoang Giang, Dao Phuong Sy, Bui Tien Toan, Nguyen Linh Song, Le Huu Bang, Mai Hong Wedemeyer, Heiner Meyer, Christian G. Kremsner, Peter G. Bock, C.-Thomas Velavan, Thirumalaisamy P. Sci Rep Article Hepatitis D caused by the hepatitis delta virus (HDV) is a serious health problem in many regions of the world. A total of 546 HBV-infected patients were enrolled from 2013 to 2015 and classified clinically into the subgroups of chronic hepatitis B (CHB, n = 191), liver cirrhosis (LC, n = 147) and hepatocellular carcinoma (HCC, n = 208). The patients were screened for HDV-RNA by nested PCR assays. HDV genotypes were assessed by direct sequencing, followed by phylogenetic analysis. HDV-RNA was identified in 13% (71/546) of HBV-infected patients. The highest HDV prevalence was found in the LC group (19.7%), followed by the HCC (12%) and CHB (8.9%) groups (P = 0.017). HDV/HBV coinfections were significantly associated with a rather unfavourable clinical outcome, in particular with LC development compared to HBV monoinfection. Phylogenetic analyses indicated that the genotype HDV1 was, with a prevalence of 91%, by far the most common genotype in Vietnam, followed by HDV2 with 9%. Other HDV genotypes were not observed. In accordance with previous data obtained a decade ago, our results confirm a continuing high prevalence of HDV infection in hepatitis B patients in northern Vietnam with the HDV1 genotype still being the predominant genotype. HDV nucleic acid testing to minimize the associated risk should be considered. Nature Publishing Group UK 2018-05-23 /pmc/articles/PMC5966401/ /pubmed/29795302 http://dx.doi.org/10.1038/s41598-018-26446-w Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Binh, Mai Thanh Hoan, Nghiem Xuan Van Tong, Hoang Giang, Dao Phuong Sy, Bui Tien Toan, Nguyen Linh Song, Le Huu Bang, Mai Hong Wedemeyer, Heiner Meyer, Christian G. Kremsner, Peter G. Bock, C.-Thomas Velavan, Thirumalaisamy P. HDV infection rates in northern Vietnam |
title | HDV infection rates in northern Vietnam |
title_full | HDV infection rates in northern Vietnam |
title_fullStr | HDV infection rates in northern Vietnam |
title_full_unstemmed | HDV infection rates in northern Vietnam |
title_short | HDV infection rates in northern Vietnam |
title_sort | hdv infection rates in northern vietnam |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966401/ https://www.ncbi.nlm.nih.gov/pubmed/29795302 http://dx.doi.org/10.1038/s41598-018-26446-w |
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