CD154 Costimulation Shifts the Local T-Cell Receptor Repertoire Not Only During Thymic Selection but Also During Peripheral T-Dependent Humoral Immune Responses

CD154 is a transmembrane cytokine expressed transiently on activated CD4 T cells upon T-cell receptor (TCR) stimulation that interacts with CD40 on antigen-presenting cells. The signaling via CD154:CD40 is essential for B-cell maturation and germinal center formation and also for the final different...

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Detalles Bibliográficos
Autores principales: Fähnrich, Anke, Klein, Sebastian, Sergé, Arnauld, Nyhoegen, Christin, Kombrink, Sabrina, Möller, Steffen, Keller, Karsten, Westermann, Jürgen, Kalies, Kathrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966529/
https://www.ncbi.nlm.nih.gov/pubmed/29867987
http://dx.doi.org/10.3389/fimmu.2018.01019

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