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A Glucagon-Like Peptide-1 Receptor Agonist Lowers Weight by Modulating the Structure of Gut Microbiota

In addition to improving glucose metabolism, liraglutide, a glucagon-like peptide-1 receptor agonist, has weight-loss effects. The underlying mechanisms are not completely understood. This study was performed to explore whether liraglutide could lower weight by modulating the composition of the gut...

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Autores principales: Zhao, Li, Chen, Yi, Xia, Fangzhen, Abudukerimu, Buatikamu, Zhang, Wen, Guo, Yuyu, Wang, Ningjian, Lu, Yingli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966539/
https://www.ncbi.nlm.nih.gov/pubmed/29867765
http://dx.doi.org/10.3389/fendo.2018.00233
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author Zhao, Li
Chen, Yi
Xia, Fangzhen
Abudukerimu, Buatikamu
Zhang, Wen
Guo, Yuyu
Wang, Ningjian
Lu, Yingli
author_facet Zhao, Li
Chen, Yi
Xia, Fangzhen
Abudukerimu, Buatikamu
Zhang, Wen
Guo, Yuyu
Wang, Ningjian
Lu, Yingli
author_sort Zhao, Li
collection PubMed
description In addition to improving glucose metabolism, liraglutide, a glucagon-like peptide-1 receptor agonist, has weight-loss effects. The underlying mechanisms are not completely understood. This study was performed to explore whether liraglutide could lower weight by modulating the composition of the gut microbiota in simple obese and diabetic obese rats. In our study, Wistar and Goto-Kakizaki (GK) rats were randomly treated with liraglutide or normal saline for 12 weeks. The biochemical parameters and metabolic hormones were measured. Hepatic glucose production and lipid metabolism were also assessed with isotope tracers. Changes in gut microbiota were analyzed by 16S rRNA gene sequencing. Both glucose and lipid metabolism were significantly improved by liraglutide. Liraglutide lowered body weight independent of glycemia status. The abundance and diversity of gut microbiota were considerably decreased by liraglutide. Liraglutide also decreased obesity-related microbial phenotypes and increased lean-related phenotypes. In conclusion, liraglutide can prevent weight gain by modulating the gut microbiota composition in both simple obese and diabetic obese subjects.
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spelling pubmed-59665392018-06-04 A Glucagon-Like Peptide-1 Receptor Agonist Lowers Weight by Modulating the Structure of Gut Microbiota Zhao, Li Chen, Yi Xia, Fangzhen Abudukerimu, Buatikamu Zhang, Wen Guo, Yuyu Wang, Ningjian Lu, Yingli Front Endocrinol (Lausanne) Endocrinology In addition to improving glucose metabolism, liraglutide, a glucagon-like peptide-1 receptor agonist, has weight-loss effects. The underlying mechanisms are not completely understood. This study was performed to explore whether liraglutide could lower weight by modulating the composition of the gut microbiota in simple obese and diabetic obese rats. In our study, Wistar and Goto-Kakizaki (GK) rats were randomly treated with liraglutide or normal saline for 12 weeks. The biochemical parameters and metabolic hormones were measured. Hepatic glucose production and lipid metabolism were also assessed with isotope tracers. Changes in gut microbiota were analyzed by 16S rRNA gene sequencing. Both glucose and lipid metabolism were significantly improved by liraglutide. Liraglutide lowered body weight independent of glycemia status. The abundance and diversity of gut microbiota were considerably decreased by liraglutide. Liraglutide also decreased obesity-related microbial phenotypes and increased lean-related phenotypes. In conclusion, liraglutide can prevent weight gain by modulating the gut microbiota composition in both simple obese and diabetic obese subjects. Frontiers Media S.A. 2018-05-17 /pmc/articles/PMC5966539/ /pubmed/29867765 http://dx.doi.org/10.3389/fendo.2018.00233 Text en Copyright © 2018 Zhao, Chen, Xia, Abudukerimu, Zhang, Guo, Wang and Lu. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Zhao, Li
Chen, Yi
Xia, Fangzhen
Abudukerimu, Buatikamu
Zhang, Wen
Guo, Yuyu
Wang, Ningjian
Lu, Yingli
A Glucagon-Like Peptide-1 Receptor Agonist Lowers Weight by Modulating the Structure of Gut Microbiota
title A Glucagon-Like Peptide-1 Receptor Agonist Lowers Weight by Modulating the Structure of Gut Microbiota
title_full A Glucagon-Like Peptide-1 Receptor Agonist Lowers Weight by Modulating the Structure of Gut Microbiota
title_fullStr A Glucagon-Like Peptide-1 Receptor Agonist Lowers Weight by Modulating the Structure of Gut Microbiota
title_full_unstemmed A Glucagon-Like Peptide-1 Receptor Agonist Lowers Weight by Modulating the Structure of Gut Microbiota
title_short A Glucagon-Like Peptide-1 Receptor Agonist Lowers Weight by Modulating the Structure of Gut Microbiota
title_sort glucagon-like peptide-1 receptor agonist lowers weight by modulating the structure of gut microbiota
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966539/
https://www.ncbi.nlm.nih.gov/pubmed/29867765
http://dx.doi.org/10.3389/fendo.2018.00233
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