Current Therapeutic Strategies for Adipose Tissue Defects/Repair Using Engineered Biomaterials and Biomolecule Formulations

Tissue engineered scaffolds for adipose restoration/repair has significantly evolved in recent years. Patients requiring soft tissue reconstruction, caused by defects or pathology, require biomaterials that will restore void volume with new functional tissue. The gold standard of autologous fat graf...

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Detalles Bibliográficos
Autores principales: Mahoney, Christopher M., Imbarlina, Cayla, Yates, Cecelia C., Marra, Kacey G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966552/
https://www.ncbi.nlm.nih.gov/pubmed/29867506
http://dx.doi.org/10.3389/fphar.2018.00507
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author Mahoney, Christopher M.
Imbarlina, Cayla
Yates, Cecelia C.
Marra, Kacey G.
author_facet Mahoney, Christopher M.
Imbarlina, Cayla
Yates, Cecelia C.
Marra, Kacey G.
author_sort Mahoney, Christopher M.
collection PubMed
description Tissue engineered scaffolds for adipose restoration/repair has significantly evolved in recent years. Patients requiring soft tissue reconstruction, caused by defects or pathology, require biomaterials that will restore void volume with new functional tissue. The gold standard of autologous fat grafting (AFG) is not a reliable option. This review focuses on the latest therapeutic strategies for the treatment of adipose tissue defects using biomolecule formulations and delivery, and specifically engineered biomaterials. Additionally, the clinical need for reliable off-the-shelf therapies, animal models, and challenges facing current technologies are discussed.
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spelling pubmed-59665522018-06-04 Current Therapeutic Strategies for Adipose Tissue Defects/Repair Using Engineered Biomaterials and Biomolecule Formulations Mahoney, Christopher M. Imbarlina, Cayla Yates, Cecelia C. Marra, Kacey G. Front Pharmacol Pharmacology Tissue engineered scaffolds for adipose restoration/repair has significantly evolved in recent years. Patients requiring soft tissue reconstruction, caused by defects or pathology, require biomaterials that will restore void volume with new functional tissue. The gold standard of autologous fat grafting (AFG) is not a reliable option. This review focuses on the latest therapeutic strategies for the treatment of adipose tissue defects using biomolecule formulations and delivery, and specifically engineered biomaterials. Additionally, the clinical need for reliable off-the-shelf therapies, animal models, and challenges facing current technologies are discussed. Frontiers Media S.A. 2018-05-17 /pmc/articles/PMC5966552/ /pubmed/29867506 http://dx.doi.org/10.3389/fphar.2018.00507 Text en Copyright © 2018 Mahoney, Imbarlina, Yates and Marra. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Mahoney, Christopher M.
Imbarlina, Cayla
Yates, Cecelia C.
Marra, Kacey G.
Current Therapeutic Strategies for Adipose Tissue Defects/Repair Using Engineered Biomaterials and Biomolecule Formulations
title Current Therapeutic Strategies for Adipose Tissue Defects/Repair Using Engineered Biomaterials and Biomolecule Formulations
title_full Current Therapeutic Strategies for Adipose Tissue Defects/Repair Using Engineered Biomaterials and Biomolecule Formulations
title_fullStr Current Therapeutic Strategies for Adipose Tissue Defects/Repair Using Engineered Biomaterials and Biomolecule Formulations
title_full_unstemmed Current Therapeutic Strategies for Adipose Tissue Defects/Repair Using Engineered Biomaterials and Biomolecule Formulations
title_short Current Therapeutic Strategies for Adipose Tissue Defects/Repair Using Engineered Biomaterials and Biomolecule Formulations
title_sort current therapeutic strategies for adipose tissue defects/repair using engineered biomaterials and biomolecule formulations
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966552/
https://www.ncbi.nlm.nih.gov/pubmed/29867506
http://dx.doi.org/10.3389/fphar.2018.00507
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