Simple Methods and Rational Design for Enhancing Aptamer Sensitivity and Specificity

Aptamers are structured nucleic acid molecules that can bind to their targets with high affinity and specificity. However, conventional SELEX (Systematic Evolution of Ligands by EXponential enrichment) methods may not necessarily produce aptamers of desired affinity and specificity. Thus, to address...

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Detalles Bibliográficos
Autores principales: Kalra, Priya, Dhiman, Abhijeet, Cho, William C., Bruno, John G., Sharma, Tarun K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966647/
https://www.ncbi.nlm.nih.gov/pubmed/29868605
http://dx.doi.org/10.3389/fmolb.2018.00041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966647/
https://www.ncbi.nlm.nih.gov/pubmed/29868605
http://dx.doi.org/10.3389/fmolb.2018.00041

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