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Implications of Antioxidant Systems in Inflammatory Bowel Disease
The global incidence of inflammatory bowel disease (IBD), a group of chronic gastrointestinal disorders, has been rising. The preponderance of evidence demonstrates that oxidative stress (OS) performs a critical function in the onset of IBD and the manner of its development. The purpose of this revi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966678/ https://www.ncbi.nlm.nih.gov/pubmed/29854724 http://dx.doi.org/10.1155/2018/1290179 |
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author | Guan, Guiping Lan, Shile |
author_facet | Guan, Guiping Lan, Shile |
author_sort | Guan, Guiping |
collection | PubMed |
description | The global incidence of inflammatory bowel disease (IBD), a group of chronic gastrointestinal disorders, has been rising. The preponderance of evidence demonstrates that oxidative stress (OS) performs a critical function in the onset of IBD and the manner of its development. The purpose of this review is to outline the generation of reactive oxygen species and antioxidant defense mechanisms in the gastrointestinal tract and the role played by OS in marking the onset and development of IBD. Furthermore, the review demonstrates the various ways through which OS is related to genetic susceptibility and the mucosal immune response. The experimental results suggest that certain therapeutic regimens for IBD could have a favorable impact by scavenging free radicals, reducing cytokine and prooxidative enzyme concentrations, and improving the antioxidative capabilities of cells. However, antioxidative activity characterized by a high level of specificity may be fundamental for the development of clinical therapies and for relapsing IBD patients. Therefore, additional research is required to clarify the ways through which OS is related to the pathogenesis and progression of IBD. |
format | Online Article Text |
id | pubmed-5966678 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-59666782018-05-31 Implications of Antioxidant Systems in Inflammatory Bowel Disease Guan, Guiping Lan, Shile Biomed Res Int Review Article The global incidence of inflammatory bowel disease (IBD), a group of chronic gastrointestinal disorders, has been rising. The preponderance of evidence demonstrates that oxidative stress (OS) performs a critical function in the onset of IBD and the manner of its development. The purpose of this review is to outline the generation of reactive oxygen species and antioxidant defense mechanisms in the gastrointestinal tract and the role played by OS in marking the onset and development of IBD. Furthermore, the review demonstrates the various ways through which OS is related to genetic susceptibility and the mucosal immune response. The experimental results suggest that certain therapeutic regimens for IBD could have a favorable impact by scavenging free radicals, reducing cytokine and prooxidative enzyme concentrations, and improving the antioxidative capabilities of cells. However, antioxidative activity characterized by a high level of specificity may be fundamental for the development of clinical therapies and for relapsing IBD patients. Therefore, additional research is required to clarify the ways through which OS is related to the pathogenesis and progression of IBD. Hindawi 2018-05-09 /pmc/articles/PMC5966678/ /pubmed/29854724 http://dx.doi.org/10.1155/2018/1290179 Text en Copyright © 2018 Guiping Guan and Shile Lan. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Guan, Guiping Lan, Shile Implications of Antioxidant Systems in Inflammatory Bowel Disease |
title | Implications of Antioxidant Systems in Inflammatory Bowel Disease |
title_full | Implications of Antioxidant Systems in Inflammatory Bowel Disease |
title_fullStr | Implications of Antioxidant Systems in Inflammatory Bowel Disease |
title_full_unstemmed | Implications of Antioxidant Systems in Inflammatory Bowel Disease |
title_short | Implications of Antioxidant Systems in Inflammatory Bowel Disease |
title_sort | implications of antioxidant systems in inflammatory bowel disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966678/ https://www.ncbi.nlm.nih.gov/pubmed/29854724 http://dx.doi.org/10.1155/2018/1290179 |
work_keys_str_mv | AT guanguiping implicationsofantioxidantsystemsininflammatoryboweldisease AT lanshile implicationsofantioxidantsystemsininflammatoryboweldisease |