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Implications of Antioxidant Systems in Inflammatory Bowel Disease

The global incidence of inflammatory bowel disease (IBD), a group of chronic gastrointestinal disorders, has been rising. The preponderance of evidence demonstrates that oxidative stress (OS) performs a critical function in the onset of IBD and the manner of its development. The purpose of this revi...

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Detalles Bibliográficos
Autores principales: Guan, Guiping, Lan, Shile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966678/
https://www.ncbi.nlm.nih.gov/pubmed/29854724
http://dx.doi.org/10.1155/2018/1290179
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author Guan, Guiping
Lan, Shile
author_facet Guan, Guiping
Lan, Shile
author_sort Guan, Guiping
collection PubMed
description The global incidence of inflammatory bowel disease (IBD), a group of chronic gastrointestinal disorders, has been rising. The preponderance of evidence demonstrates that oxidative stress (OS) performs a critical function in the onset of IBD and the manner of its development. The purpose of this review is to outline the generation of reactive oxygen species and antioxidant defense mechanisms in the gastrointestinal tract and the role played by OS in marking the onset and development of IBD. Furthermore, the review demonstrates the various ways through which OS is related to genetic susceptibility and the mucosal immune response. The experimental results suggest that certain therapeutic regimens for IBD could have a favorable impact by scavenging free radicals, reducing cytokine and prooxidative enzyme concentrations, and improving the antioxidative capabilities of cells. However, antioxidative activity characterized by a high level of specificity may be fundamental for the development of clinical therapies and for relapsing IBD patients. Therefore, additional research is required to clarify the ways through which OS is related to the pathogenesis and progression of IBD.
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spelling pubmed-59666782018-05-31 Implications of Antioxidant Systems in Inflammatory Bowel Disease Guan, Guiping Lan, Shile Biomed Res Int Review Article The global incidence of inflammatory bowel disease (IBD), a group of chronic gastrointestinal disorders, has been rising. The preponderance of evidence demonstrates that oxidative stress (OS) performs a critical function in the onset of IBD and the manner of its development. The purpose of this review is to outline the generation of reactive oxygen species and antioxidant defense mechanisms in the gastrointestinal tract and the role played by OS in marking the onset and development of IBD. Furthermore, the review demonstrates the various ways through which OS is related to genetic susceptibility and the mucosal immune response. The experimental results suggest that certain therapeutic regimens for IBD could have a favorable impact by scavenging free radicals, reducing cytokine and prooxidative enzyme concentrations, and improving the antioxidative capabilities of cells. However, antioxidative activity characterized by a high level of specificity may be fundamental for the development of clinical therapies and for relapsing IBD patients. Therefore, additional research is required to clarify the ways through which OS is related to the pathogenesis and progression of IBD. Hindawi 2018-05-09 /pmc/articles/PMC5966678/ /pubmed/29854724 http://dx.doi.org/10.1155/2018/1290179 Text en Copyright © 2018 Guiping Guan and Shile Lan. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Guan, Guiping
Lan, Shile
Implications of Antioxidant Systems in Inflammatory Bowel Disease
title Implications of Antioxidant Systems in Inflammatory Bowel Disease
title_full Implications of Antioxidant Systems in Inflammatory Bowel Disease
title_fullStr Implications of Antioxidant Systems in Inflammatory Bowel Disease
title_full_unstemmed Implications of Antioxidant Systems in Inflammatory Bowel Disease
title_short Implications of Antioxidant Systems in Inflammatory Bowel Disease
title_sort implications of antioxidant systems in inflammatory bowel disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966678/
https://www.ncbi.nlm.nih.gov/pubmed/29854724
http://dx.doi.org/10.1155/2018/1290179
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