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Role of ROS and Nutritional Antioxidants in Human Diseases
The overproduction of reactive oxygen species (ROS) has been implicated in the development of various chronic and degenerative diseases such as cancer, respiratory, neurodegenerative, and digestive diseases. Under physiological conditions, the concentrations of ROS are subtlety regulated by antioxid...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966868/ https://www.ncbi.nlm.nih.gov/pubmed/29867535 http://dx.doi.org/10.3389/fphys.2018.00477 |
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author | Liu, Zewen Ren, Zhangpin Zhang, Jun Chuang, Chia-Chen Kandaswamy, Eswar Zhou, Tingyang Zuo, Li |
author_facet | Liu, Zewen Ren, Zhangpin Zhang, Jun Chuang, Chia-Chen Kandaswamy, Eswar Zhou, Tingyang Zuo, Li |
author_sort | Liu, Zewen |
collection | PubMed |
description | The overproduction of reactive oxygen species (ROS) has been implicated in the development of various chronic and degenerative diseases such as cancer, respiratory, neurodegenerative, and digestive diseases. Under physiological conditions, the concentrations of ROS are subtlety regulated by antioxidants, which can be either generated endogenously or externally supplemented. A combination of antioxidant-deficiency and malnutrition may render individuals more vulnerable to oxidative stress, thereby increasing the risk of cancer occurrence. In addition, antioxidant defense can be overwhelmed during sustained inflammation such as in chronic obstructive pulmonary diseases, inflammatory bowel disease, and neurodegenerative disorders, cardiovascular diseases, and aging. Certain antioxidant vitamins, such as vitamin D, are essential in regulating biochemical pathways that lead to the proper functioning of the organs. Antioxidant supplementation has been shown to attenuate endogenous antioxidant depletion thus alleviating associated oxidative damage in some clinical research. However, some results indicate that antioxidants exert no favorable effects on disease control. Thus, more studies are warranted to investigate the complicated interactions between ROS and different types of antioxidants for restoration of the redox balance under pathologic conditions. This review highlights the potential roles of ROS and nutritional antioxidants in the pathogenesis of several redox imbalance-related diseases and the attenuation of oxidative stress-induced damages. |
format | Online Article Text |
id | pubmed-5966868 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-59668682018-06-04 Role of ROS and Nutritional Antioxidants in Human Diseases Liu, Zewen Ren, Zhangpin Zhang, Jun Chuang, Chia-Chen Kandaswamy, Eswar Zhou, Tingyang Zuo, Li Front Physiol Physiology The overproduction of reactive oxygen species (ROS) has been implicated in the development of various chronic and degenerative diseases such as cancer, respiratory, neurodegenerative, and digestive diseases. Under physiological conditions, the concentrations of ROS are subtlety regulated by antioxidants, which can be either generated endogenously or externally supplemented. A combination of antioxidant-deficiency and malnutrition may render individuals more vulnerable to oxidative stress, thereby increasing the risk of cancer occurrence. In addition, antioxidant defense can be overwhelmed during sustained inflammation such as in chronic obstructive pulmonary diseases, inflammatory bowel disease, and neurodegenerative disorders, cardiovascular diseases, and aging. Certain antioxidant vitamins, such as vitamin D, are essential in regulating biochemical pathways that lead to the proper functioning of the organs. Antioxidant supplementation has been shown to attenuate endogenous antioxidant depletion thus alleviating associated oxidative damage in some clinical research. However, some results indicate that antioxidants exert no favorable effects on disease control. Thus, more studies are warranted to investigate the complicated interactions between ROS and different types of antioxidants for restoration of the redox balance under pathologic conditions. This review highlights the potential roles of ROS and nutritional antioxidants in the pathogenesis of several redox imbalance-related diseases and the attenuation of oxidative stress-induced damages. Frontiers Media S.A. 2018-05-17 /pmc/articles/PMC5966868/ /pubmed/29867535 http://dx.doi.org/10.3389/fphys.2018.00477 Text en Copyright © 2018 Liu, Ren, Zhang, Chuang, Kandaswamy, Zhou and Zuo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Liu, Zewen Ren, Zhangpin Zhang, Jun Chuang, Chia-Chen Kandaswamy, Eswar Zhou, Tingyang Zuo, Li Role of ROS and Nutritional Antioxidants in Human Diseases |
title | Role of ROS and Nutritional Antioxidants in Human Diseases |
title_full | Role of ROS and Nutritional Antioxidants in Human Diseases |
title_fullStr | Role of ROS and Nutritional Antioxidants in Human Diseases |
title_full_unstemmed | Role of ROS and Nutritional Antioxidants in Human Diseases |
title_short | Role of ROS and Nutritional Antioxidants in Human Diseases |
title_sort | role of ros and nutritional antioxidants in human diseases |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966868/ https://www.ncbi.nlm.nih.gov/pubmed/29867535 http://dx.doi.org/10.3389/fphys.2018.00477 |
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