Cargando…

Role of ROS and Nutritional Antioxidants in Human Diseases

The overproduction of reactive oxygen species (ROS) has been implicated in the development of various chronic and degenerative diseases such as cancer, respiratory, neurodegenerative, and digestive diseases. Under physiological conditions, the concentrations of ROS are subtlety regulated by antioxid...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Zewen, Ren, Zhangpin, Zhang, Jun, Chuang, Chia-Chen, Kandaswamy, Eswar, Zhou, Tingyang, Zuo, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966868/
https://www.ncbi.nlm.nih.gov/pubmed/29867535
http://dx.doi.org/10.3389/fphys.2018.00477
_version_ 1783325524166180864
author Liu, Zewen
Ren, Zhangpin
Zhang, Jun
Chuang, Chia-Chen
Kandaswamy, Eswar
Zhou, Tingyang
Zuo, Li
author_facet Liu, Zewen
Ren, Zhangpin
Zhang, Jun
Chuang, Chia-Chen
Kandaswamy, Eswar
Zhou, Tingyang
Zuo, Li
author_sort Liu, Zewen
collection PubMed
description The overproduction of reactive oxygen species (ROS) has been implicated in the development of various chronic and degenerative diseases such as cancer, respiratory, neurodegenerative, and digestive diseases. Under physiological conditions, the concentrations of ROS are subtlety regulated by antioxidants, which can be either generated endogenously or externally supplemented. A combination of antioxidant-deficiency and malnutrition may render individuals more vulnerable to oxidative stress, thereby increasing the risk of cancer occurrence. In addition, antioxidant defense can be overwhelmed during sustained inflammation such as in chronic obstructive pulmonary diseases, inflammatory bowel disease, and neurodegenerative disorders, cardiovascular diseases, and aging. Certain antioxidant vitamins, such as vitamin D, are essential in regulating biochemical pathways that lead to the proper functioning of the organs. Antioxidant supplementation has been shown to attenuate endogenous antioxidant depletion thus alleviating associated oxidative damage in some clinical research. However, some results indicate that antioxidants exert no favorable effects on disease control. Thus, more studies are warranted to investigate the complicated interactions between ROS and different types of antioxidants for restoration of the redox balance under pathologic conditions. This review highlights the potential roles of ROS and nutritional antioxidants in the pathogenesis of several redox imbalance-related diseases and the attenuation of oxidative stress-induced damages.
format Online
Article
Text
id pubmed-5966868
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-59668682018-06-04 Role of ROS and Nutritional Antioxidants in Human Diseases Liu, Zewen Ren, Zhangpin Zhang, Jun Chuang, Chia-Chen Kandaswamy, Eswar Zhou, Tingyang Zuo, Li Front Physiol Physiology The overproduction of reactive oxygen species (ROS) has been implicated in the development of various chronic and degenerative diseases such as cancer, respiratory, neurodegenerative, and digestive diseases. Under physiological conditions, the concentrations of ROS are subtlety regulated by antioxidants, which can be either generated endogenously or externally supplemented. A combination of antioxidant-deficiency and malnutrition may render individuals more vulnerable to oxidative stress, thereby increasing the risk of cancer occurrence. In addition, antioxidant defense can be overwhelmed during sustained inflammation such as in chronic obstructive pulmonary diseases, inflammatory bowel disease, and neurodegenerative disorders, cardiovascular diseases, and aging. Certain antioxidant vitamins, such as vitamin D, are essential in regulating biochemical pathways that lead to the proper functioning of the organs. Antioxidant supplementation has been shown to attenuate endogenous antioxidant depletion thus alleviating associated oxidative damage in some clinical research. However, some results indicate that antioxidants exert no favorable effects on disease control. Thus, more studies are warranted to investigate the complicated interactions between ROS and different types of antioxidants for restoration of the redox balance under pathologic conditions. This review highlights the potential roles of ROS and nutritional antioxidants in the pathogenesis of several redox imbalance-related diseases and the attenuation of oxidative stress-induced damages. Frontiers Media S.A. 2018-05-17 /pmc/articles/PMC5966868/ /pubmed/29867535 http://dx.doi.org/10.3389/fphys.2018.00477 Text en Copyright © 2018 Liu, Ren, Zhang, Chuang, Kandaswamy, Zhou and Zuo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Liu, Zewen
Ren, Zhangpin
Zhang, Jun
Chuang, Chia-Chen
Kandaswamy, Eswar
Zhou, Tingyang
Zuo, Li
Role of ROS and Nutritional Antioxidants in Human Diseases
title Role of ROS and Nutritional Antioxidants in Human Diseases
title_full Role of ROS and Nutritional Antioxidants in Human Diseases
title_fullStr Role of ROS and Nutritional Antioxidants in Human Diseases
title_full_unstemmed Role of ROS and Nutritional Antioxidants in Human Diseases
title_short Role of ROS and Nutritional Antioxidants in Human Diseases
title_sort role of ros and nutritional antioxidants in human diseases
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966868/
https://www.ncbi.nlm.nih.gov/pubmed/29867535
http://dx.doi.org/10.3389/fphys.2018.00477
work_keys_str_mv AT liuzewen roleofrosandnutritionalantioxidantsinhumandiseases
AT renzhangpin roleofrosandnutritionalantioxidantsinhumandiseases
AT zhangjun roleofrosandnutritionalantioxidantsinhumandiseases
AT chuangchiachen roleofrosandnutritionalantioxidantsinhumandiseases
AT kandaswamyeswar roleofrosandnutritionalantioxidantsinhumandiseases
AT zhoutingyang roleofrosandnutritionalantioxidantsinhumandiseases
AT zuoli roleofrosandnutritionalantioxidantsinhumandiseases