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Associations of discretionary screen time with mortality, cardiovascular disease and cancer are attenuated by strength, fitness and physical activity: findings from the UK Biobank study

BACKGROUND: Discretionary screen time (time spent viewing a television or computer screen during leisure time) is an important contributor to total sedentary behaviour, which is associated with increased risk of mortality and cardiovascular disease (CVD). The aim of this study was to determine wheth...

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Autores principales: Celis-Morales, Carlos A., Lyall, Donald M., Steell, Lewis, Gray, Stuart R., Iliodromiti, Stamatina, Anderson, Jana, Mackay, Daniel F., Welsh, Paul, Yates, Thomas, Pell, Jill P., Sattar, Naveed, Gill, Jason M. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966877/
https://www.ncbi.nlm.nih.gov/pubmed/29792209
http://dx.doi.org/10.1186/s12916-018-1063-1
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author Celis-Morales, Carlos A.
Lyall, Donald M.
Steell, Lewis
Gray, Stuart R.
Iliodromiti, Stamatina
Anderson, Jana
Mackay, Daniel F.
Welsh, Paul
Yates, Thomas
Pell, Jill P.
Sattar, Naveed
Gill, Jason M. R.
author_facet Celis-Morales, Carlos A.
Lyall, Donald M.
Steell, Lewis
Gray, Stuart R.
Iliodromiti, Stamatina
Anderson, Jana
Mackay, Daniel F.
Welsh, Paul
Yates, Thomas
Pell, Jill P.
Sattar, Naveed
Gill, Jason M. R.
author_sort Celis-Morales, Carlos A.
collection PubMed
description BACKGROUND: Discretionary screen time (time spent viewing a television or computer screen during leisure time) is an important contributor to total sedentary behaviour, which is associated with increased risk of mortality and cardiovascular disease (CVD). The aim of this study was to determine whether the associations of screen time with cardiovascular disease and all-cause mortality were modified by levels of cardiorespiratory fitness, grip strength or physical activity. METHODS: In total, 390,089 participants (54% women) from the UK Biobank were included in this study. All-cause mortality, CVD and cancer incidence and mortality were the main outcomes. Discretionary television (TV) viewing, personal computer (PC) screen time and overall screen time (TV + PC time) were the exposure variables. Grip strength, fitness and physical activity were treated as potential effect modifiers. RESULTS: Altogether, 7420 participants died, and there were 22,210 CVD events, over a median of 5.0 years follow-up (interquartile range 4.3 to 5.7; after exclusion of the first 2 years from baseline in the landmark analysis). All discretionary screen-time exposures were significantly associated with all health outcomes. The associations of overall discretionary screen time with all-cause mortality and incidence of CVD and cancer were strongest amongst participants in the lowest tertile for grip strength (all-cause mortality hazard ratio per 2-h increase in screen time (1.31 [95% confidence interval: 1.22–1.43], p < 0.0001; CVD 1.21 [1.13–1.30], p = 0.0001; cancer incidence 1.14 [1.10–1.19], p < 0.0001) and weakest amongst those in the highest grip-strength tertile (all-cause mortality 1.04 [0.95–1.14], p = 0.198; CVD 1.05 [0.99–1.11], p = 0.070; cancer 0.98 [0.93–1.05], p = 0.771). Similar trends were found for fitness (lowest fitness tertile: all-cause mortality 1.23 [1.13–1.34], p = 0.002 and CVD 1.10 [1.02–1.22], p = 0.010; highest fitness tertile: all-cause mortality 1.12 [0.96–1.28], p = 0.848 and CVD 1.01 [0.96–1.07], p = 0.570). Similar findings were found for physical activity for all-cause mortality and cancer incidence. CONCLUSIONS: The associations between discretionary screen time and adverse health outcomes were strongest in those with low grip strength, fitness and physical activity and markedly attenuated in those with the highest levels of grip strength, fitness and physical activity. Thus, if these associations are causal, the greatest benefits from health promotion interventions to reduce discretionary screen time may be seen in those with low levels of strength, fitness and physical activity. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12916-018-1063-1) contains supplementary material, which is available to authorized users.
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spelling pubmed-59668772018-05-24 Associations of discretionary screen time with mortality, cardiovascular disease and cancer are attenuated by strength, fitness and physical activity: findings from the UK Biobank study Celis-Morales, Carlos A. Lyall, Donald M. Steell, Lewis Gray, Stuart R. Iliodromiti, Stamatina Anderson, Jana Mackay, Daniel F. Welsh, Paul Yates, Thomas Pell, Jill P. Sattar, Naveed Gill, Jason M. R. BMC Med Research Article BACKGROUND: Discretionary screen time (time spent viewing a television or computer screen during leisure time) is an important contributor to total sedentary behaviour, which is associated with increased risk of mortality and cardiovascular disease (CVD). The aim of this study was to determine whether the associations of screen time with cardiovascular disease and all-cause mortality were modified by levels of cardiorespiratory fitness, grip strength or physical activity. METHODS: In total, 390,089 participants (54% women) from the UK Biobank were included in this study. All-cause mortality, CVD and cancer incidence and mortality were the main outcomes. Discretionary television (TV) viewing, personal computer (PC) screen time and overall screen time (TV + PC time) were the exposure variables. Grip strength, fitness and physical activity were treated as potential effect modifiers. RESULTS: Altogether, 7420 participants died, and there were 22,210 CVD events, over a median of 5.0 years follow-up (interquartile range 4.3 to 5.7; after exclusion of the first 2 years from baseline in the landmark analysis). All discretionary screen-time exposures were significantly associated with all health outcomes. The associations of overall discretionary screen time with all-cause mortality and incidence of CVD and cancer were strongest amongst participants in the lowest tertile for grip strength (all-cause mortality hazard ratio per 2-h increase in screen time (1.31 [95% confidence interval: 1.22–1.43], p < 0.0001; CVD 1.21 [1.13–1.30], p = 0.0001; cancer incidence 1.14 [1.10–1.19], p < 0.0001) and weakest amongst those in the highest grip-strength tertile (all-cause mortality 1.04 [0.95–1.14], p = 0.198; CVD 1.05 [0.99–1.11], p = 0.070; cancer 0.98 [0.93–1.05], p = 0.771). Similar trends were found for fitness (lowest fitness tertile: all-cause mortality 1.23 [1.13–1.34], p = 0.002 and CVD 1.10 [1.02–1.22], p = 0.010; highest fitness tertile: all-cause mortality 1.12 [0.96–1.28], p = 0.848 and CVD 1.01 [0.96–1.07], p = 0.570). Similar findings were found for physical activity for all-cause mortality and cancer incidence. CONCLUSIONS: The associations between discretionary screen time and adverse health outcomes were strongest in those with low grip strength, fitness and physical activity and markedly attenuated in those with the highest levels of grip strength, fitness and physical activity. Thus, if these associations are causal, the greatest benefits from health promotion interventions to reduce discretionary screen time may be seen in those with low levels of strength, fitness and physical activity. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12916-018-1063-1) contains supplementary material, which is available to authorized users. BioMed Central 2018-05-24 /pmc/articles/PMC5966877/ /pubmed/29792209 http://dx.doi.org/10.1186/s12916-018-1063-1 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Celis-Morales, Carlos A.
Lyall, Donald M.
Steell, Lewis
Gray, Stuart R.
Iliodromiti, Stamatina
Anderson, Jana
Mackay, Daniel F.
Welsh, Paul
Yates, Thomas
Pell, Jill P.
Sattar, Naveed
Gill, Jason M. R.
Associations of discretionary screen time with mortality, cardiovascular disease and cancer are attenuated by strength, fitness and physical activity: findings from the UK Biobank study
title Associations of discretionary screen time with mortality, cardiovascular disease and cancer are attenuated by strength, fitness and physical activity: findings from the UK Biobank study
title_full Associations of discretionary screen time with mortality, cardiovascular disease and cancer are attenuated by strength, fitness and physical activity: findings from the UK Biobank study
title_fullStr Associations of discretionary screen time with mortality, cardiovascular disease and cancer are attenuated by strength, fitness and physical activity: findings from the UK Biobank study
title_full_unstemmed Associations of discretionary screen time with mortality, cardiovascular disease and cancer are attenuated by strength, fitness and physical activity: findings from the UK Biobank study
title_short Associations of discretionary screen time with mortality, cardiovascular disease and cancer are attenuated by strength, fitness and physical activity: findings from the UK Biobank study
title_sort associations of discretionary screen time with mortality, cardiovascular disease and cancer are attenuated by strength, fitness and physical activity: findings from the uk biobank study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966877/
https://www.ncbi.nlm.nih.gov/pubmed/29792209
http://dx.doi.org/10.1186/s12916-018-1063-1
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