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Integrated time course omics analysis distinguishes immediate therapeutic response from acquired resistance

BACKGROUND: Targeted therapies specifically act by blocking the activity of proteins that are encoded by genes critical for tumorigenesis. However, most cancers acquire resistance and long-term disease remission is rarely observed. Understanding the time course of molecular changes responsible for t...

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Detalles Bibliográficos
Autores principales:	Stein-O’Brien, Genevieve, Kagohara, Luciane T., Li, Sijia, Thakar, Manjusha, Ranaweera, Ruchira, Ozawa, Hiroyuki, Cheng, Haixia, Considine, Michael, Schmitz, Sandra, Favorov, Alexander V., Danilova, Ludmila V., Califano, Joseph A., Izumchenko, Evgeny, Gaykalova, Daria A., Chung, Christine H., Fertig, Elana J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966898/ https://www.ncbi.nlm.nih.gov/pubmed/29792227 http://dx.doi.org/10.1186/s13073-018-0545-2

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