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Safety and Efficacy of Aerobic Exercise Training Associated to Non-Invasive Ventilation in Patients with Acute Heart Failure

BACKGROUND: Exercise training (ET) improves functional capacity in chronic heart failure (HF). However, ET effects in acute HF are unknown. OBJECTIVE: To investigate the effects of ET alone or combined with noninvasive ventilation (NIV) compared with standard medical treatment during hospitalization...

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Autores principales: Oliveira, Mayron F., Santos, Rita C., Artz, Suellen A., Mendez, Vanessa M. F., Lobo, Denise M. L., Correia, Edileide B., Ferraz, Almir S., Umeda, Iracema I. K., Sperandio, Priscila A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Cardiologia - SBC 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967141/
https://www.ncbi.nlm.nih.gov/pubmed/29538506
http://dx.doi.org/10.5935/abc.20180039
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author Oliveira, Mayron F.
Santos, Rita C.
Artz, Suellen A.
Mendez, Vanessa M. F.
Lobo, Denise M. L.
Correia, Edileide B.
Ferraz, Almir S.
Umeda, Iracema I. K.
Sperandio, Priscila A.
author_facet Oliveira, Mayron F.
Santos, Rita C.
Artz, Suellen A.
Mendez, Vanessa M. F.
Lobo, Denise M. L.
Correia, Edileide B.
Ferraz, Almir S.
Umeda, Iracema I. K.
Sperandio, Priscila A.
author_sort Oliveira, Mayron F.
collection PubMed
description BACKGROUND: Exercise training (ET) improves functional capacity in chronic heart failure (HF). However, ET effects in acute HF are unknown. OBJECTIVE: To investigate the effects of ET alone or combined with noninvasive ventilation (NIV) compared with standard medical treatment during hospitalization in acute HF patients. METHODS: Twenty-nine patients (systolic HF) were randomized into three groups: control (Control - only standard medical treatment); ET with placebo NIV (ET+Sham) and ET+NIV (NIV with 14 and 8 cmH(2)O of inspiratory and expiratory pressure, respectively). The 6MWT was performed on day 1 and day 10 of hospitalization and the ET was performed on an unloaded cycle ergometer until patients' tolerance limit (20 min or less) for eight consecutive days. For all analyses, statistical significance was set at 5% (p < 0.05). RESULTS: None of the patients in either exercise groups had adverse events or required exercise interruption. The 6MWT distance was greater in ET+NIV (Δ120 ± 72 m) than in ET+Sham (Δ73 ± 26 m) and Control (Δ45 ± 32 m; p < 0.05). Total exercise time was greater (128 ± 10 vs. 92 ± 8 min; p < 0.05) and dyspnea was lower (3 ± 1 vs. 4 ± 1; p < 0.05) in ET+NIV than ET+Sham. The ET+NIV group had a shorter hospital stay (17 ± 10 days) than ET+Sham (23 ± 8 days) and Control (39 ± 15 days) groups (p < 0.05). Total exercise time in ET+Sham and ET+NIV had significant correlation with length of hospital stay (r = -0.75; p = 0.01). CONCLUSION: Exercise training in acute HF was safe, had no adverse events and, when combined with NIV, improved 6MWT and reduce dyspnea and length of stay.
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spelling pubmed-59671412018-05-30 Safety and Efficacy of Aerobic Exercise Training Associated to Non-Invasive Ventilation in Patients with Acute Heart Failure Oliveira, Mayron F. Santos, Rita C. Artz, Suellen A. Mendez, Vanessa M. F. Lobo, Denise M. L. Correia, Edileide B. Ferraz, Almir S. Umeda, Iracema I. K. Sperandio, Priscila A. Arq Bras Cardiol Original Article BACKGROUND: Exercise training (ET) improves functional capacity in chronic heart failure (HF). However, ET effects in acute HF are unknown. OBJECTIVE: To investigate the effects of ET alone or combined with noninvasive ventilation (NIV) compared with standard medical treatment during hospitalization in acute HF patients. METHODS: Twenty-nine patients (systolic HF) were randomized into three groups: control (Control - only standard medical treatment); ET with placebo NIV (ET+Sham) and ET+NIV (NIV with 14 and 8 cmH(2)O of inspiratory and expiratory pressure, respectively). The 6MWT was performed on day 1 and day 10 of hospitalization and the ET was performed on an unloaded cycle ergometer until patients' tolerance limit (20 min or less) for eight consecutive days. For all analyses, statistical significance was set at 5% (p < 0.05). RESULTS: None of the patients in either exercise groups had adverse events or required exercise interruption. The 6MWT distance was greater in ET+NIV (Δ120 ± 72 m) than in ET+Sham (Δ73 ± 26 m) and Control (Δ45 ± 32 m; p < 0.05). Total exercise time was greater (128 ± 10 vs. 92 ± 8 min; p < 0.05) and dyspnea was lower (3 ± 1 vs. 4 ± 1; p < 0.05) in ET+NIV than ET+Sham. The ET+NIV group had a shorter hospital stay (17 ± 10 days) than ET+Sham (23 ± 8 days) and Control (39 ± 15 days) groups (p < 0.05). Total exercise time in ET+Sham and ET+NIV had significant correlation with length of hospital stay (r = -0.75; p = 0.01). CONCLUSION: Exercise training in acute HF was safe, had no adverse events and, when combined with NIV, improved 6MWT and reduce dyspnea and length of stay. Sociedade Brasileira de Cardiologia - SBC 2018-05 /pmc/articles/PMC5967141/ /pubmed/29538506 http://dx.doi.org/10.5935/abc.20180039 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Oliveira, Mayron F.
Santos, Rita C.
Artz, Suellen A.
Mendez, Vanessa M. F.
Lobo, Denise M. L.
Correia, Edileide B.
Ferraz, Almir S.
Umeda, Iracema I. K.
Sperandio, Priscila A.
Safety and Efficacy of Aerobic Exercise Training Associated to Non-Invasive Ventilation in Patients with Acute Heart Failure
title Safety and Efficacy of Aerobic Exercise Training Associated to Non-Invasive Ventilation in Patients with Acute Heart Failure
title_full Safety and Efficacy of Aerobic Exercise Training Associated to Non-Invasive Ventilation in Patients with Acute Heart Failure
title_fullStr Safety and Efficacy of Aerobic Exercise Training Associated to Non-Invasive Ventilation in Patients with Acute Heart Failure
title_full_unstemmed Safety and Efficacy of Aerobic Exercise Training Associated to Non-Invasive Ventilation in Patients with Acute Heart Failure
title_short Safety and Efficacy of Aerobic Exercise Training Associated to Non-Invasive Ventilation in Patients with Acute Heart Failure
title_sort safety and efficacy of aerobic exercise training associated to non-invasive ventilation in patients with acute heart failure
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967141/
https://www.ncbi.nlm.nih.gov/pubmed/29538506
http://dx.doi.org/10.5935/abc.20180039
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