An inhibitory pull-push circuit in frontal cortex

Push-pull is a canonical computation of excitatory cortical circuits. Here we identify a pull-push inhibitory circuit in frontal cortex that originates in vasoactive intestinal polypeptide (VIP) expressing interneurons. During arousal, VIP cells rapidly and directly inhibit pyramidal neurons; VIP ce...

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Detalles Bibliográficos
Autores principales: Garcia-Junco-Clemente, Pablo, Ikrar, Taruna, Tring, Elaine, Xu, Xiangmin, Ringach, Dario L., Trachtenberg, Joshua T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967235/
https://www.ncbi.nlm.nih.gov/pubmed/28114295
http://dx.doi.org/10.1038/nn.4483
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author Garcia-Junco-Clemente, Pablo
Ikrar, Taruna
Tring, Elaine
Xu, Xiangmin
Ringach, Dario L.
Trachtenberg, Joshua T.
author_facet Garcia-Junco-Clemente, Pablo
Ikrar, Taruna
Tring, Elaine
Xu, Xiangmin
Ringach, Dario L.
Trachtenberg, Joshua T.
author_sort Garcia-Junco-Clemente, Pablo
collection PubMed
description Push-pull is a canonical computation of excitatory cortical circuits. Here we identify a pull-push inhibitory circuit in frontal cortex that originates in vasoactive intestinal polypeptide (VIP) expressing interneurons. During arousal, VIP cells rapidly and directly inhibit pyramidal neurons; VIP cells also indirectly excite these pyramidal neurons via parallel disinhibition. Thus, arousal exerts a feed-back pull-push influence on excitatory neurons – an inversion of the canonical push-pull of feed-forward input.
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spelling pubmed-59672352018-05-24 An inhibitory pull-push circuit in frontal cortex Garcia-Junco-Clemente, Pablo Ikrar, Taruna Tring, Elaine Xu, Xiangmin Ringach, Dario L. Trachtenberg, Joshua T. Nat Neurosci Article Push-pull is a canonical computation of excitatory cortical circuits. Here we identify a pull-push inhibitory circuit in frontal cortex that originates in vasoactive intestinal polypeptide (VIP) expressing interneurons. During arousal, VIP cells rapidly and directly inhibit pyramidal neurons; VIP cells also indirectly excite these pyramidal neurons via parallel disinhibition. Thus, arousal exerts a feed-back pull-push influence on excitatory neurons – an inversion of the canonical push-pull of feed-forward input. 2017-01-23 2017-03 /pmc/articles/PMC5967235/ /pubmed/28114295 http://dx.doi.org/10.1038/nn.4483 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Garcia-Junco-Clemente, Pablo
Ikrar, Taruna
Tring, Elaine
Xu, Xiangmin
Ringach, Dario L.
Trachtenberg, Joshua T.
An inhibitory pull-push circuit in frontal cortex
title An inhibitory pull-push circuit in frontal cortex
title_full An inhibitory pull-push circuit in frontal cortex
title_fullStr An inhibitory pull-push circuit in frontal cortex
title_full_unstemmed An inhibitory pull-push circuit in frontal cortex
title_short An inhibitory pull-push circuit in frontal cortex
title_sort inhibitory pull-push circuit in frontal cortex
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967235/
https://www.ncbi.nlm.nih.gov/pubmed/28114295
http://dx.doi.org/10.1038/nn.4483
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