Effects of single amino acid deficiency on mRNA translation are markedly different for methionine versus leucine

Although amino acids are known regulators of translation, the unique contributions of specific amino acids are not well understood. We compared effects of culturing HEK293T cells in medium lacking either leucine, methionine, histidine, or arginine on eIF2 and 4EBP1 phosphorylation and measures of mR...

Descripción completa

Detalles Bibliográficos
Autores principales: Mazor, Kevin M., Dong, Leiming, Mao, Yuanhui, Swanda, Robert V., Qian, Shu-Bing, Stipanuk, Martha H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967319/
https://www.ncbi.nlm.nih.gov/pubmed/29795412
http://dx.doi.org/10.1038/s41598-018-26254-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967319/
https://www.ncbi.nlm.nih.gov/pubmed/29795412
http://dx.doi.org/10.1038/s41598-018-26254-2

Ejemplares similares