Codon optimization and improved delivery/immunization regimen enhance the immune response against wild-type and drug-resistant HIV-1 reverse transcriptase, preserving its Th2-polarity

DNA vaccines require a considerable enhancement of immunogenicity. Here, we optimized a prototype DNA vaccine against drug-resistant HIV-1 based on a weak Th2-immunogen, HIV-1 reverse transcriptase (RT). We designed expression-optimized genes encoding inactivated wild-type and drug-resistant RTs (RT...

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Detalles Bibliográficos
Autores principales: Latanova, A. A., Petkov, S., Kilpelainen, A., Jansons, J., Latyshev, O. E., Kuzmenko, Y. V., Hinkula, J., Abakumov, M. A., Valuev-Elliston, V. T., Gomelsky, M., Karpov, V. L., Chiodi, F., Wahren, B., Logunov, D. Y., Starodubova, E. S., Isaguliants, M. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967322/
https://www.ncbi.nlm.nih.gov/pubmed/29799015
http://dx.doi.org/10.1038/s41598-018-26281-z

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