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Intolerance of uncertainty and conditioned place preference in opioid addiction

Several personality factors have been implicated in vulnerability to addiction by impacting learning and decision making. One such factor is intolerance of uncertainty (IU), the tendency to perceive uncertain situations negatively and avoid them. Conditioned place preference (CPP), which compares pr...

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Autores principales: Radell, Milen L., Allen, Michael Todd, Favaloro, Belinda, Myers, Catherine E., Haber, Paul, Morley, Kirsten, Moustafa, Ahmed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967368/
https://www.ncbi.nlm.nih.gov/pubmed/29844956
http://dx.doi.org/10.7717/peerj.4775
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author Radell, Milen L.
Allen, Michael Todd
Favaloro, Belinda
Myers, Catherine E.
Haber, Paul
Morley, Kirsten
Moustafa, Ahmed A.
author_facet Radell, Milen L.
Allen, Michael Todd
Favaloro, Belinda
Myers, Catherine E.
Haber, Paul
Morley, Kirsten
Moustafa, Ahmed A.
author_sort Radell, Milen L.
collection PubMed
description Several personality factors have been implicated in vulnerability to addiction by impacting learning and decision making. One such factor is intolerance of uncertainty (IU), the tendency to perceive uncertain situations negatively and avoid them. Conditioned place preference (CPP), which compares preference for contexts paired with reward, has been used to examine the motivation for both drug and non-drug rewards. However, preference for locations associated with non-drug reward, as well as the potential influence of IU, has not been thoroughly studied in individuals with addiction. In the current study, we examined CPP using a computer-based task in a sample of addicted individuals undergoing opioid maintenance treatment and never-addicted controls. Patients were confirmed to have higher IU than controls. In the CPP task, the two groups did not differ in overall time spent in the previously-rewarded context. However, controls were more likely than patients to immediately return to this context. Contrary to our predictions, IU was not a significant predictor of preference for the previously-rewarded context, although higher IU in controls was associated with a higher number of rewards obtained in the task. No such relationship was found in patients.
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spelling pubmed-59673682018-05-29 Intolerance of uncertainty and conditioned place preference in opioid addiction Radell, Milen L. Allen, Michael Todd Favaloro, Belinda Myers, Catherine E. Haber, Paul Morley, Kirsten Moustafa, Ahmed A. PeerJ Psychiatry and Psychology Several personality factors have been implicated in vulnerability to addiction by impacting learning and decision making. One such factor is intolerance of uncertainty (IU), the tendency to perceive uncertain situations negatively and avoid them. Conditioned place preference (CPP), which compares preference for contexts paired with reward, has been used to examine the motivation for both drug and non-drug rewards. However, preference for locations associated with non-drug reward, as well as the potential influence of IU, has not been thoroughly studied in individuals with addiction. In the current study, we examined CPP using a computer-based task in a sample of addicted individuals undergoing opioid maintenance treatment and never-addicted controls. Patients were confirmed to have higher IU than controls. In the CPP task, the two groups did not differ in overall time spent in the previously-rewarded context. However, controls were more likely than patients to immediately return to this context. Contrary to our predictions, IU was not a significant predictor of preference for the previously-rewarded context, although higher IU in controls was associated with a higher number of rewards obtained in the task. No such relationship was found in patients. PeerJ Inc. 2018-05-21 /pmc/articles/PMC5967368/ /pubmed/29844956 http://dx.doi.org/10.7717/peerj.4775 Text en ©2018 Radell et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Psychiatry and Psychology
Radell, Milen L.
Allen, Michael Todd
Favaloro, Belinda
Myers, Catherine E.
Haber, Paul
Morley, Kirsten
Moustafa, Ahmed A.
Intolerance of uncertainty and conditioned place preference in opioid addiction
title Intolerance of uncertainty and conditioned place preference in opioid addiction
title_full Intolerance of uncertainty and conditioned place preference in opioid addiction
title_fullStr Intolerance of uncertainty and conditioned place preference in opioid addiction
title_full_unstemmed Intolerance of uncertainty and conditioned place preference in opioid addiction
title_short Intolerance of uncertainty and conditioned place preference in opioid addiction
title_sort intolerance of uncertainty and conditioned place preference in opioid addiction
topic Psychiatry and Psychology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967368/
https://www.ncbi.nlm.nih.gov/pubmed/29844956
http://dx.doi.org/10.7717/peerj.4775
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