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Discrepancies in the evaluation of the safety of the human papillomavirus vaccine
Despite being more than ten years since its introduction, global acceptance to the human papillomavirus (HPV) vaccine is still low. The immunogenetic background of the host, and HPV antigen recognition, are important in natural HPV infection, and should be taken into account in the understanding of...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Instituto Oswaldo Cruz, Ministério da Saúde
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967601/ https://www.ncbi.nlm.nih.gov/pubmed/29846395 http://dx.doi.org/10.1590/0074-02760180063 |
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author | Cervantes, Jorge L Doan, Amy Hoanganh |
author_facet | Cervantes, Jorge L Doan, Amy Hoanganh |
author_sort | Cervantes, Jorge L |
collection | PubMed |
description | Despite being more than ten years since its introduction, global acceptance to the human papillomavirus (HPV) vaccine is still low. The immunogenetic background of the host, and HPV antigen recognition, are important in natural HPV infection, and should be taken into account in the understanding of adverse autoimmune reactions by the HPV vaccine in certain groups. There is no doubt of the benefit of vaccines in the reduction of the incidence of infectious diseases, and in the case of HPV, the prevention of persistent infection that would lead to cervical cancer. Side-effects, however, should be closely monitored and reported without any bias, to ensure that the benefits of vaccines outweigh the risks of adverse reactions. In this article we bring the attention on certain adverse effects of the vaccine against HPV that have not been well studied as they are not well defined. We also compare the different approaches on HPV vaccine policies regarding its adverse reactions in countries like Japan and Colombia, vs. the recommendations issued by the WHO. |
format | Online Article Text |
id | pubmed-5967601 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Instituto Oswaldo Cruz, Ministério da Saúde |
record_format | MEDLINE/PubMed |
spelling | pubmed-59676012018-05-31 Discrepancies in the evaluation of the safety of the human papillomavirus vaccine Cervantes, Jorge L Doan, Amy Hoanganh Mem Inst Oswaldo Cruz Perspectives Despite being more than ten years since its introduction, global acceptance to the human papillomavirus (HPV) vaccine is still low. The immunogenetic background of the host, and HPV antigen recognition, are important in natural HPV infection, and should be taken into account in the understanding of adverse autoimmune reactions by the HPV vaccine in certain groups. There is no doubt of the benefit of vaccines in the reduction of the incidence of infectious diseases, and in the case of HPV, the prevention of persistent infection that would lead to cervical cancer. Side-effects, however, should be closely monitored and reported without any bias, to ensure that the benefits of vaccines outweigh the risks of adverse reactions. In this article we bring the attention on certain adverse effects of the vaccine against HPV that have not been well studied as they are not well defined. We also compare the different approaches on HPV vaccine policies regarding its adverse reactions in countries like Japan and Colombia, vs. the recommendations issued by the WHO. Instituto Oswaldo Cruz, Ministério da Saúde 2018-05-28 /pmc/articles/PMC5967601/ /pubmed/29846395 http://dx.doi.org/10.1590/0074-02760180063 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Perspectives Cervantes, Jorge L Doan, Amy Hoanganh Discrepancies in the evaluation of the safety of the human papillomavirus vaccine |
title | Discrepancies in the evaluation of the safety of the human papillomavirus vaccine |
title_full | Discrepancies in the evaluation of the safety of the human papillomavirus vaccine |
title_fullStr | Discrepancies in the evaluation of the safety of the human papillomavirus vaccine |
title_full_unstemmed | Discrepancies in the evaluation of the safety of the human papillomavirus vaccine |
title_short | Discrepancies in the evaluation of the safety of the human papillomavirus vaccine |
title_sort | discrepancies in the evaluation of the safety of the human papillomavirus vaccine |
topic | Perspectives |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967601/ https://www.ncbi.nlm.nih.gov/pubmed/29846395 http://dx.doi.org/10.1590/0074-02760180063 |
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