Synthetic single domain antibodies for the conformational trapping of membrane proteins

Mechanistic and structural studies of membrane proteins require their stabilization in specific conformations. Single domain antibodies are potent reagents for this purpose, but their generation relies on immunizations, which impedes selections in the presence of ligands typically needed to populate...

Descripción completa

Detalles Bibliográficos
Autores principales: Zimmermann, Iwan, Egloff, Pascal, Hutter, Cedric AJ, Arnold, Fabian M, Stohler, Peter, Bocquet, Nicolas, Hug, Melanie N, Huber, Sylwia, Siegrist, Martin, Hetemann, Lisa, Gera, Jennifer, Gmür, Samira, Spies, Peter, Gygax, Daniel, Geertsma, Eric R, Dawson, Roger JP, Seeger, Markus A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967865/
https://www.ncbi.nlm.nih.gov/pubmed/29792401
http://dx.doi.org/10.7554/eLife.34317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967865/
https://www.ncbi.nlm.nih.gov/pubmed/29792401
http://dx.doi.org/10.7554/eLife.34317

Ejemplares similares