One-pot synthesis of GSH-Capped CdTe quantum dots with excellent biocompatibility for direct cell imaging

In this work, we have developed one-pot aqueous synthesis of glutathione (GSH) binding CdTe quantum dots (QDs) for cell imaging. UV-Vis absorption spectrum, Fourier transform infrared spectrum, photoluminescence spectrum, and high-resolution transmission electron microscopy are applied to characterize the physical and chemical properties of the nanocomposites. The bioimaging efficiency of the GSH-capped CdTe QDs is further evaluated on Hela cells. The groups on the surface of QDs are able to bind to basic proteins, which are abundant in cell nuclei, enabling the application of QDs for direct cell imaging. Experimental results also indicate the GSH layer on the surface of QDs is able to reduce the cytotoxicity significantly. In conclusion, the as-prepared GSH-capped QDs are highly promising fluorescent probes for cell imaging in the near future.