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Unexpected role of the L-domain of calpastatin during the autoproteolytic activation of human erythrocyte calpain
Autoproteolysis of human erythrocyte calpain-1 proceeds in vitro at high [Ca(2+)], through the conversion of the 80-kDa catalytic subunit into a 75-kDa activated enzyme that requires lower [Ca(2+)] for catalysis. Importantly, here we detect a similar 75 kDa calpain-1 form also in vivo, in human meni...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Portland Press Ltd.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968184/ https://www.ncbi.nlm.nih.gov/pubmed/29572388 http://dx.doi.org/10.1042/BSR20180147 |