Autologous Bone Marrow Transplantation for Polymyositis Combined with Myasthenia Gravis and Aplastic Anemia: A Case Report

This is the first report about a patient with concomitant polymyositis (PM), myasthenia gravis (MG), and aplastic anemia (AA). A 54-year-old male developed myalgia and muscle weakness, which gradually progressed over 2 months. He was persistently affected by MG and AA. Brachium magnetic resonance im...

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Autores principales: Mitsumune, Sho, Manabe, Yasuhiro, Yunoki, Taijun, Kono, Shyoichiro, Aoyama, Kazutoshi, Shinno, Yoko, Narai, Hisashi, Abe, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968255/
https://www.ncbi.nlm.nih.gov/pubmed/29805377
http://dx.doi.org/10.1159/000488476
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author Mitsumune, Sho
Manabe, Yasuhiro
Yunoki, Taijun
Kono, Shyoichiro
Aoyama, Kazutoshi
Shinno, Yoko
Narai, Hisashi
Abe, Koji
author_facet Mitsumune, Sho
Manabe, Yasuhiro
Yunoki, Taijun
Kono, Shyoichiro
Aoyama, Kazutoshi
Shinno, Yoko
Narai, Hisashi
Abe, Koji
author_sort Mitsumune, Sho
collection PubMed
description This is the first report about a patient with concomitant polymyositis (PM), myasthenia gravis (MG), and aplastic anemia (AA). A 54-year-old male developed myalgia and muscle weakness, which gradually progressed over 2 months. He was persistently affected by MG and AA. Brachium magnetic resonance imaging showed increased signal intensity in the left triceps and deltoid muscles on short tau inversion recovery images. A muscle biopsy examination revealed perifascicular atrophication and inflammatory myopathy. We diagnosed the patient with PM combined with MG and AA. He was successfully treated with an autologous bone marrow transplantation (BMT). The present case suggests that BMT is a therapeutic option for PM, MG, and AA.
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spelling pubmed-59682552018-05-25 Autologous Bone Marrow Transplantation for Polymyositis Combined with Myasthenia Gravis and Aplastic Anemia: A Case Report Mitsumune, Sho Manabe, Yasuhiro Yunoki, Taijun Kono, Shyoichiro Aoyama, Kazutoshi Shinno, Yoko Narai, Hisashi Abe, Koji Case Rep Neurol Case Report This is the first report about a patient with concomitant polymyositis (PM), myasthenia gravis (MG), and aplastic anemia (AA). A 54-year-old male developed myalgia and muscle weakness, which gradually progressed over 2 months. He was persistently affected by MG and AA. Brachium magnetic resonance imaging showed increased signal intensity in the left triceps and deltoid muscles on short tau inversion recovery images. A muscle biopsy examination revealed perifascicular atrophication and inflammatory myopathy. We diagnosed the patient with PM combined with MG and AA. He was successfully treated with an autologous bone marrow transplantation (BMT). The present case suggests that BMT is a therapeutic option for PM, MG, and AA. S. Karger AG 2018-04-17 /pmc/articles/PMC5968255/ /pubmed/29805377 http://dx.doi.org/10.1159/000488476 Text en Copyright © 2018 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Mitsumune, Sho
Manabe, Yasuhiro
Yunoki, Taijun
Kono, Shyoichiro
Aoyama, Kazutoshi
Shinno, Yoko
Narai, Hisashi
Abe, Koji
Autologous Bone Marrow Transplantation for Polymyositis Combined with Myasthenia Gravis and Aplastic Anemia: A Case Report
title Autologous Bone Marrow Transplantation for Polymyositis Combined with Myasthenia Gravis and Aplastic Anemia: A Case Report
title_full Autologous Bone Marrow Transplantation for Polymyositis Combined with Myasthenia Gravis and Aplastic Anemia: A Case Report
title_fullStr Autologous Bone Marrow Transplantation for Polymyositis Combined with Myasthenia Gravis and Aplastic Anemia: A Case Report
title_full_unstemmed Autologous Bone Marrow Transplantation for Polymyositis Combined with Myasthenia Gravis and Aplastic Anemia: A Case Report
title_short Autologous Bone Marrow Transplantation for Polymyositis Combined with Myasthenia Gravis and Aplastic Anemia: A Case Report
title_sort autologous bone marrow transplantation for polymyositis combined with myasthenia gravis and aplastic anemia: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968255/
https://www.ncbi.nlm.nih.gov/pubmed/29805377
http://dx.doi.org/10.1159/000488476
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