Pamidronate Rescue Therapy for Hypercalcemia in a Child With Williams Syndrome

A 15-month-old male infant diagnosed with Williams Syndrome (WS) was admitted with severe hypercalcemia and nephrocalcinosis. Intravenous hydration and furosemide failed to yield an appreciable and sustainable fall in serum calcium, while the injection of pamidronate achieved a significant decrease...

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Autores principales: Sanjad, Sami A., Aoun, Bilal, Yammine, Halim, Bassyouni, Amina, Karam, Pascale E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968380/
https://www.ncbi.nlm.nih.gov/pubmed/29867772
http://dx.doi.org/10.3389/fendo.2018.00240
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author Sanjad, Sami A.
Aoun, Bilal
Yammine, Halim
Bassyouni, Amina
Karam, Pascale E.
author_facet Sanjad, Sami A.
Aoun, Bilal
Yammine, Halim
Bassyouni, Amina
Karam, Pascale E.
author_sort Sanjad, Sami A.
collection PubMed
description A 15-month-old male infant diagnosed with Williams Syndrome (WS) was admitted with severe hypercalcemia and nephrocalcinosis. Intravenous hydration and furosemide failed to yield an appreciable and sustainable fall in serum calcium, while the injection of pamidronate achieved a significant decrease in serum calcium in a short period of time. This bisphosphonate could be considered as a second-line treatment for refractory hypercalcemia in WS.
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spelling pubmed-59683802018-06-04 Pamidronate Rescue Therapy for Hypercalcemia in a Child With Williams Syndrome Sanjad, Sami A. Aoun, Bilal Yammine, Halim Bassyouni, Amina Karam, Pascale E. Front Endocrinol (Lausanne) Endocrinology A 15-month-old male infant diagnosed with Williams Syndrome (WS) was admitted with severe hypercalcemia and nephrocalcinosis. Intravenous hydration and furosemide failed to yield an appreciable and sustainable fall in serum calcium, while the injection of pamidronate achieved a significant decrease in serum calcium in a short period of time. This bisphosphonate could be considered as a second-line treatment for refractory hypercalcemia in WS. Frontiers Media S.A. 2018-05-14 /pmc/articles/PMC5968380/ /pubmed/29867772 http://dx.doi.org/10.3389/fendo.2018.00240 Text en Copyright © 2018 Sanjad, Aoun, Yammine, Bassyouni and Karam. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Sanjad, Sami A.
Aoun, Bilal
Yammine, Halim
Bassyouni, Amina
Karam, Pascale E.
Pamidronate Rescue Therapy for Hypercalcemia in a Child With Williams Syndrome
title Pamidronate Rescue Therapy for Hypercalcemia in a Child With Williams Syndrome
title_full Pamidronate Rescue Therapy for Hypercalcemia in a Child With Williams Syndrome
title_fullStr Pamidronate Rescue Therapy for Hypercalcemia in a Child With Williams Syndrome
title_full_unstemmed Pamidronate Rescue Therapy for Hypercalcemia in a Child With Williams Syndrome
title_short Pamidronate Rescue Therapy for Hypercalcemia in a Child With Williams Syndrome
title_sort pamidronate rescue therapy for hypercalcemia in a child with williams syndrome
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968380/
https://www.ncbi.nlm.nih.gov/pubmed/29867772
http://dx.doi.org/10.3389/fendo.2018.00240
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