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β2-microglobulin induces depressive- and anxiety-like behaviors in rat
β(2)-microglobulin (B2M), the light chain of major histocompatibility complex class I (MHC I) molecules, has been found to impair hippocampal neurogenesis. Based on the crucial role of hippocampal neurogenesis disturbance in the process of depression and anxiety, the aim of the present study is to i...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968416/ https://www.ncbi.nlm.nih.gov/pubmed/29795686 http://dx.doi.org/10.1371/journal.pone.0198027 |
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author | Zhang, Ping Zeng, Dan Yi, Yi-Li Tang, Yi-Yun Zou, Wei Yang, Xue-Feng Wang, Chun-Yan Tang, Xiao-Qing |
author_facet | Zhang, Ping Zeng, Dan Yi, Yi-Li Tang, Yi-Yun Zou, Wei Yang, Xue-Feng Wang, Chun-Yan Tang, Xiao-Qing |
author_sort | Zhang, Ping |
collection | PubMed |
description | β(2)-microglobulin (B2M), the light chain of major histocompatibility complex class I (MHC I) molecules, has been found to impair hippocampal neurogenesis. Based on the crucial role of hippocampal neurogenesis disturbance in the process of depression and anxiety, the aim of the present study is to investigate whether B2M leads to depressive- and anxiety-like behaviors. We found that 6 days after intracerebroventricular injection with B2M (0.3 μg), the immobility times of rats in the tail suspension test and the forced swimming test were increased, the swimming and climbing time in the forced swimming test was decreased, and the latency to feed in the novelty-suppressed feeding test was increased, indicating that B2M induces depressive-like behaviors. In addition, in the elevated plus maze test, B2M-treated rats displayed obvious decline in the number of entries into and the proportion of time spent in the open arm, while the number of total arm entries was no change, which indicated that B2M induces anxiety-like behaviors. Our present findings suggest that target B2M might represent a novel approach for treatment of depression and anxiety. |
format | Online Article Text |
id | pubmed-5968416 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-59684162018-06-08 β2-microglobulin induces depressive- and anxiety-like behaviors in rat Zhang, Ping Zeng, Dan Yi, Yi-Li Tang, Yi-Yun Zou, Wei Yang, Xue-Feng Wang, Chun-Yan Tang, Xiao-Qing PLoS One Research Article β(2)-microglobulin (B2M), the light chain of major histocompatibility complex class I (MHC I) molecules, has been found to impair hippocampal neurogenesis. Based on the crucial role of hippocampal neurogenesis disturbance in the process of depression and anxiety, the aim of the present study is to investigate whether B2M leads to depressive- and anxiety-like behaviors. We found that 6 days after intracerebroventricular injection with B2M (0.3 μg), the immobility times of rats in the tail suspension test and the forced swimming test were increased, the swimming and climbing time in the forced swimming test was decreased, and the latency to feed in the novelty-suppressed feeding test was increased, indicating that B2M induces depressive-like behaviors. In addition, in the elevated plus maze test, B2M-treated rats displayed obvious decline in the number of entries into and the proportion of time spent in the open arm, while the number of total arm entries was no change, which indicated that B2M induces anxiety-like behaviors. Our present findings suggest that target B2M might represent a novel approach for treatment of depression and anxiety. Public Library of Science 2018-05-24 /pmc/articles/PMC5968416/ /pubmed/29795686 http://dx.doi.org/10.1371/journal.pone.0198027 Text en © 2018 Zhang et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Zhang, Ping Zeng, Dan Yi, Yi-Li Tang, Yi-Yun Zou, Wei Yang, Xue-Feng Wang, Chun-Yan Tang, Xiao-Qing β2-microglobulin induces depressive- and anxiety-like behaviors in rat |
title | β2-microglobulin induces depressive- and anxiety-like behaviors in rat |
title_full | β2-microglobulin induces depressive- and anxiety-like behaviors in rat |
title_fullStr | β2-microglobulin induces depressive- and anxiety-like behaviors in rat |
title_full_unstemmed | β2-microglobulin induces depressive- and anxiety-like behaviors in rat |
title_short | β2-microglobulin induces depressive- and anxiety-like behaviors in rat |
title_sort | β2-microglobulin induces depressive- and anxiety-like behaviors in rat |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968416/ https://www.ncbi.nlm.nih.gov/pubmed/29795686 http://dx.doi.org/10.1371/journal.pone.0198027 |
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