Neurexin controls plasticity of a mature, sexually dimorphic neuron

During development and adulthood, brain plasticity is evident at several levels, from synaptic structure and function to outgrowth of dendrites and axons. Whether and how sex impinges on neuronal plasticity is poorly understood. Here we show that the C. elegans sex-shared GABAergic DVB neuron displays experience-dependent and sexually dimorphic morphologic plasticity, characterized by the stochastic and dynamic addition of multiple neurites in adult males. These added neurites enable synaptic rewiring of the DVB neuron, instructing a functional switch of the neuron and directly modifying a step of male mating behavior, both of which are altered by experience and post-synaptic activity manipulations. We show that the outgrowth of DVB neurites is promoted by presynaptic NRX-1/neurexin and restricted by postsynaptic NLG-1/neuroligin, providing a novel context in which these two molecules operate.